PMID- 25561293
OWN - NLM
STAT- MEDLINE
DCOM- 20151123
LR  - 20181113
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Print)
IS  - 2042-6976 (Linking)
VI  - 5
IP  - 3
DP  - 2015 Mar
TI  - Vitamin D3 as a novel regulator of basic fibroblast growth factor in chronic 
      rhinosinusitis with nasal polyposis.
PG  - 191-6
LID - 10.1002/alr.21474 [doi]
AB  - BACKGROUND: The immunopathogenesis of chronic rhinosinusitis (CRS) is largely 
      unknown, but it is thought that different inflammatory profiles are responsible 
      for the different CRS subtypes. 25-Hydroxyvitamin-D (25-VD3) has been shown to 
      alter inflammatory mediators in other disease processes and 25-VD3 deficiency is 
      associated with CRS with nasal polyps (CRSwNP), but it is unknown if 25-VD3 
      levels impact local inflammation in CRS. This study investigated the correlation 
      between plasma 25-VD3 and sinonasal mucus monocyte chemoattractant protein-1 
      (MCP-1), regulated upon activation normal T cell expressed and secreted (RANTES), 
      and basic fibroblast growth factor (bFGF) levels in patients with CRS. METHODS: 
      Study subjects undergoing endoscopic sinus surgery (ESS) for CRS were 
      prospectively enrolled from January 2012 to August 2014. Control subjects 
      included patients undergoing ESS for noninflammatory pathology. Blood and 
      sinonasal mucus were collected at the time of ESS. Plasma 25-VD3 was measured by 
      enzyme-linked immunosorbent assay (ELISA) and mucus levels of MCP-1, RANTES, and 
      bFGF by cytometric bead array (CBA). RESULTS: A total of 57 patients were 
      enrolled and categorized as CRS without nasal polyps (CRSsNP) (n = 31), CRSwNP (n 
      = 14), and controls (n = 12). No significant correlation was found between MCP-1 
      and 25-VD3. There was a significant negative correlation between 25-VD3 and 
      RANTES (r = -0.612; p = 0.026) and bFGF (r = -0.578; p = 0.039) in CRSwNP 
      patients; however, there was no significant correlation in CRSsNP patients. 
      CONCLUSION: This data suggests that 25-VD3 may play a role in regulation of 
      RANTES and bFGF expression in CRSwNP. This may occur through regulation of NP 
      fibroblasts or other immune cells. Further investigation is warranted to better 
      elucidate the role of RANTES, bFGF, and 25-VD3 in CRSwNP.
CI  - (c) 2015 ARS-AAOA, LLC.
FAU - Sansoni, E Ritter
AU  - Sansoni ER
AD  - Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science 
      University, Portland, OR.
FAU - Sautter, Nathan B
AU  - Sautter NB
FAU - Mace, Jess C
AU  - Mace JC
FAU - Smith, Timothy L
AU  - Smith TL
FAU - Yawn, James R
AU  - Yawn JR
FAU - Lawrence, Lauren A
AU  - Lawrence LA
FAU - Schlosser, Rodney J
AU  - Schlosser RJ
FAU - Soler, Zachary M
AU  - Soler ZM
FAU - Mulligan, Jennifer K
AU  - Mulligan JK
LA  - eng
SI  - ClinicalTrials.gov/NCT01332136
GR  - R01 DC005805/DC/NIDCD NIH HHS/United States
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150105
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Vitamins)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 1406-16-2 (Vitamin D)
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Chemokine CCL2/metabolism
MH  - Chemokine CCL5/drug effects
MH  - Cholecalciferol/metabolism/*pharmacology
MH  - Chronic Disease
MH  - Endoscopy/methods
MH  - Female
MH  - Fibroblast Growth Factor 2/*drug effects
MH  - Fibroblasts/drug effects/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mucus/chemistry
MH  - Nasal Polyps/blood/surgery
MH  - Rhinitis/blood/*surgery
MH  - Sinusitis/blood/surgery
MH  - Vitamin D/analogs & derivatives/metabolism
MH  - Vitamins/*pharmacology
PMC - PMC4352130
MID - NIHMS655337
OTO - NOTNLM
OT  - 25-dihydroxyvitamin D3
OT  - fibroblast growth factor-2
OT  - polyps
OT  - sinusitis
OT  - vitamin D
EDAT- 2015/01/07 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/03/01
CRDT- 2015/01/07 06:00
PHST- 2014/08/25 00:00 [received]
PHST- 2014/10/17 00:00 [revised]
PHST- 2014/11/18 00:00 [accepted]
PHST- 2015/01/07 06:00 [entrez]
PHST- 2015/01/07 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - 10.1002/alr.21474 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2015 Mar;5(3):191-6. doi: 10.1002/alr.21474. Epub 2015 
      Jan 5.