PMID- 25561876
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150106
LR  - 20220310
IS  - 1319-562X (Print)
IS  - 2213-7106 (Electronic)
IS  - 2213-7106 (Linking)
VI  - 22
IP  - 1
DP  - 2015 Jan
TI  - Alzheimer's disease and type 2 diabetes via chronic inflammatory mechanisms.
PG  - 4-13
LID - 10.1016/j.sjbs.2014.05.003 [doi]
AB  - Recent evidence has indicated that type 2 diabetes mellitus (T2DM) increases the 
      risk of developing Alzheimer's disease (AD). Therefore, it is crucial to 
      investigate the potential common processes that could explain this relation 
      between AD and T2DM. In the recent decades, an abundance of evidence has emerged 
      demonstrating that chronic inflammatory processes may be the major factors 
      contributing to the development and progression of T2DM and AD. In this article, 
      we have discussed the molecular underpinnings of inflammatory process that 
      contribute to the pathogenesis of T2DM and AD and how they are linked to these 
      two diseases. In depth understanding of the inflammatory mechanisms through which 
      AD and T2DM are associated to each other may help the researchers to develop 
      novel and more effective strategies to treat together AD and T2DM. Several 
      treatment options have been identified which spurn the inflammatory processes and 
      discourage the production of inflammatory mediators, thereby preventing or 
      slowing down the onset of T2DM and AD.
FAU - Mushtaq, Gohar
AU  - Mushtaq G
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University, P.O. 
      Box 80203, Jeddah 21589, Saudi Arabia.
FAU - Khan, Jalaluddin A
AU  - Khan JA
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University, P.O. 
      Box 80203, Jeddah 21589, Saudi Arabia.
FAU - Kumosani, Taha A
AU  - Kumosani TA
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University, P.O. 
      Box 80203, Jeddah 21589, Saudi Arabia ; King Fahd Medical Research Center, King 
      Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia.
FAU - Kamal, Mohammad A
AU  - Kamal MA
AD  - King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, 
      Jeddah 21589, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140523
PL  - Saudi Arabia
TA  - Saudi J Biol Sci
JT  - Saudi journal of biological sciences
JID - 101543796
PMC - PMC4281591
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Anti-inflammatory drugs
OT  - C-reactive protein
OT  - Cytokines
OT  - Hyperinsulinemia
OT  - Inflammation
OT  - Oxidative stress
OT  - Transgenic mouse models
OT  - Tumor necrosis factor-alpha
OT  - Type 2 diabetes mellitus
OT  - beta-Amyloid
EDAT- 2015/01/07 06:00
MHDA- 2015/01/07 06:01
PMCR- 2014/05/23
CRDT- 2015/01/07 06:00
PHST- 2014/03/27 00:00 [received]
PHST- 2014/05/13 00:00 [revised]
PHST- 2014/05/14 00:00 [accepted]
PHST- 2015/01/07 06:00 [entrez]
PHST- 2015/01/07 06:00 [pubmed]
PHST- 2015/01/07 06:01 [medline]
PHST- 2014/05/23 00:00 [pmc-release]
AID - S1319-562X(14)00042-4 [pii]
AID - 10.1016/j.sjbs.2014.05.003 [doi]
PST - ppublish
SO  - Saudi J Biol Sci. 2015 Jan;22(1):4-13. doi: 10.1016/j.sjbs.2014.05.003. Epub 2014 
      May 23.