PMID- 25561884
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150106
LR  - 20220330
IS  - 1319-562X (Print)
IS  - 2213-7106 (Electronic)
IS  - 2213-7106 (Linking)
VI  - 22
IP  - 1
DP  - 2015 Jan
TI  - Comparative study of high sensitivity troponin T and heart-type fatty 
      acid-binding protein in STEMI patients.
PG  - 56-61
LID - 10.1016/j.sjbs.2014.05.011 [doi]
AB  - AIM AND BACKGROUND: Heart-type fatty acid-binding proteins (H-FABP) which are 
      detected within 2-3 h of acute myocardial infarction are involved in uptake of 
      free fatty acids in the myocardium. Our aim in the present study is to compare 
      window periods of H-FABP to high sensitivity troponin T (hs-Trop T) in acute ST 
      elevation myocardial infarction (STEMI). METHODS: 160 STEMI diagnosed patient's 
      serum samples are analyzed for hs-Trop T and H-FABP. Different window periods of 
      chest pain onset (<3 h, 3-6 h and >6 h) are compared with complications, 
      in-hospital mortality and statistically analyzed. RESULTS: From 160 patients, 53 
      (33%) cases are presented in <3 h, 75 (47%) in 3-6, and 32 (20%) after >6 h 
      respectively. Accordingly sensitivity of hs-Trop T was 92%, 94% and 97% while 
      H-FABP was 75%, 88% and 84%, respectively. Overall sensitivity was 94% and 82% 
      respectively. Statistically significant difference between mean hs-Trop T values 
      with respect to window period <3, 3-6 and >6 h was 0.21, 0.35 and 0.80 ng/ml 
      respectively, p value < 0.0001. No significant difference in H-FABP values was 
      observed. Hs-Trop T positively correlated with age (r = 0.153, P = 0.05), window 
      period (r = 0.363, P < 0.0001), TIMI score (r = 0.208, P = 0.008), ejection 
      fraction (r = 0.191, P = 0.008), serum H-FABP (r = 0.229, P = 0.004), and serum 
      hs-CRP (r = 0.326, p < 0.001). There was a statistically significant difference 
      of mean hs-Trop T values with or without in hospital mortality (0.35 vs. 
      0.85 ng/ml, respectively, p = 0.008). No significant correlation to age, TIMI 
      score, ejection fraction and hs-CRP values for H-FABP was observed. CONCLUSION: 
      It appears that hs-Trop T is a more sensitive marker than H-FABP in early hours 
      of AMI and higher hs-Trop T predicts increase in-hospital mortality.
FAU - Banu, Shaheena
AU  - Banu S
AD  - Department of Biochemistry, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, India.
FAU - Tanveer, Syed
AU  - Tanveer S
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, India.
FAU - Manjunath, C N
AU  - Manjunath CN
AD  - Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and 
      Research, India.
LA  - eng
PT  - Journal Article
DEP - 20140610
PL  - Saudi Arabia
TA  - Saudi J Biol Sci
JT  - Saudi journal of biological sciences
JID - 101543796
PMC - PMC4281618
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Heart fatty acid binding protein
OT  - High sensitive-CRP
OT  - High sensitive-troponin T
EDAT- 2015/01/07 06:00
MHDA- 2015/01/07 06:01
PMCR- 2014/06/10
CRDT- 2015/01/07 06:00
PHST- 2014/03/19 00:00 [received]
PHST- 2014/05/29 00:00 [revised]
PHST- 2014/05/29 00:00 [accepted]
PHST- 2015/01/07 06:00 [entrez]
PHST- 2015/01/07 06:00 [pubmed]
PHST- 2015/01/07 06:01 [medline]
PHST- 2014/06/10 00:00 [pmc-release]
AID - S1319-562X(14)00050-3 [pii]
AID - 10.1016/j.sjbs.2014.05.011 [doi]
PST - ppublish
SO  - Saudi J Biol Sci. 2015 Jan;22(1):56-61. doi: 10.1016/j.sjbs.2014.05.011. Epub 
      2014 Jun 10.