PMID- 25562035
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150106
LR  - 20220408
IS  - 2093-4777 (Print)
IS  - 2093-6931 (Electronic)
IS  - 2093-4777 (Linking)
VI  - 18
IP  - 4
DP  - 2014 Dec
TI  - Aerobic exercise alleviates ischemia-induced memory impairment by enhancing cell 
      proliferation and suppressing neuronal apoptosis in hippocampus.
PG  - 187-97
LID - 10.5213/inj.2014.18.4.187 [doi]
AB  - PURPOSE: Neurogenic lower urinary tract dysfunction (NLUTD) is a possible 
      consequence of several neurological disorders. NLUTD may produce debilitating 
      symptoms and serious complications, such as chronic renal failure, and recurrent 
      urinary tract infections. Many animal studies of NLUTD symptoms have focused on 
      animal models of cerebral ischemia. In the present study, we investigated the 
      effects of treadmill exercise on memory function and its relation to cell 
      proliferation and apoptosis in the hippocampus, following transient global 
      ischemia in gerbils. METHODS: To induce transient global ischemia in gerbil, both 
      common carotid arteries were occluded for 5 minutes. Gerbils in the exercise 
      groups were forced to run on a treadmill exercise for 30 minutes once a day for 2 
      weeks. Step-down avoidance task and Y maze task were performed. Terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-staining, 
      immunohistochemistry for 5-bromo-2'-deoxyridine, doublecortin, caspase-3, and 
      Western blot for brain-derived neurotrophic factor (BDNF), Bax, Bcl-2, cytochrome 
      c, caspase-3 were conducted. RESULTS: Ischemia caused memory impairment with an 
      increase of cell proliferation, BDNF expression, and apoptosis in the 
      hippocampus. Treadmill exercise improved memory function with further increase of 
      cell proliferation and BDNF expression and a decrease of apoptosis. CONCLUSIONS: 
      The animal model that we have developed and our assessment of the relation 
      between exercise and brain function can be useful tools for future investigations 
      of NLUTD symptoms associated with stroke, particularly ischemic stroke. The 
      present study suggests that treadmill exercise promoted the recovery of brain 
      function after cerebral ischemia.
FAU - Seo, Tae-Beom
AU  - Seo TB
AD  - Division of Sports Science & Engineering, Department of Biochemistry, Korea 
      Institute of Sports Science, Seoul, Korea.
FAU - Kim, Tae-Woon
AU  - Kim TW
AD  - Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea.
FAU - Shin, Mal-Soon
AU  - Shin MS
AD  - Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea.
FAU - Ji, Eun-Sang
AU  - Ji ES
AD  - Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea.
FAU - Cho, Han-Sam
AU  - Cho HS
AD  - Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea.
FAU - Lee, Jae-Min
AU  - Lee JM
AD  - Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea.
FAU - Kim, Tae-Wook
AU  - Kim TW
AD  - Department of Physical Education, College of Physical Education, Hanyang 
      University, Seoul, Korea.
FAU - Kim, Chang-Ju
AU  - Kim CJ
AUID- ORCID: 0000-0003-4749-5795
AD  - Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20141229
PL  - Korea (South)
TA  - Int Neurourol J
JT  - International neurourology journal
JID - 101534513
PMC - PMC4280438
OTO - NOTNLM
OT  - Apoptosis
OT  - Brain-Derived Neurotrophic Factor
OT  - Cell Proliferation
OT  - Exercise Test
OT  - Ischemia
COIS- No potential conflict of interest relevant to this article was reported
EDAT- 2015/01/07 06:00
MHDA- 2015/01/07 06:01
PMCR- 2014/12/01
CRDT- 2015/01/07 06:00
PHST- 2014/11/03 00:00 [received]
PHST- 2014/12/09 00:00 [accepted]
PHST- 2015/01/07 06:00 [entrez]
PHST- 2015/01/07 06:00 [pubmed]
PHST- 2015/01/07 06:01 [medline]
PHST- 2014/12/01 00:00 [pmc-release]
AID - 10.5213/inj.2014.18.4.187 [doi]
PST - ppublish
SO  - Int Neurourol J. 2014 Dec;18(4):187-97. doi: 10.5213/inj.2014.18.4.187. Epub 2014 
      Dec 29.