PMID- 25562189
OWN - NLM
STAT- MEDLINE
DCOM- 20151201
LR  - 20220318
IS  - 1873-7528 (Electronic)
IS  - 0149-7634 (Linking)
VI  - 51
DP  - 2015 Apr
TI  - A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive 
      review.
PG  - 15-30
LID - S0149-7634(14)00355-8 [pii]
LID - 10.1016/j.neubiorev.2014.12.016 [doi]
AB  - Schizophrenia is believed to arise from complex gene-environment interactions. 
      Brain-derived neurotrophic factor (BDNF) is involved in neuronal development, 
      differentiation and plasticity. A functional single nucleotide polymorphism that 
      results in a valine (Val) to methionine (Met) substitution at codon 66 (Val66Met) 
      results in the aberrant sorting and release of mature BDNF through the 
      activity-dependent secretion pathway. The Val66Met polymorphism has been linked 
      to impaired neurocognitive function in healthy adults, and identified as a locus 
      of risk for a range of neuropsychiatric disorders including schizophrenia. Here 
      we provide a comprehensive review of the relationship between the BDNF Val66Met 
      polymorphism and schizophrenia, integrating evidence from the fields of genetic 
      epidemiology, clinical psychiatry, behavioral neuroscience and neuroimaging. We 
      argue that while the Val66Met polymorphism may not be a major risk-conferring 
      agent for the development of schizophrenia per se, there is mounting evidence 
      that the polymorphism modulates a range of clinical features of the illness, 
      including age of onset, symptoms, therapeutic responsiveness, neurocognitive 
      function and brain morphology.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Notaras, Michael
AU  - Notaras M
AD  - Behavioural Neuroscience Laboratory, Florey Institute of Neuroscience & Mental 
      Health, VIC, Australia; Psychoneuroendocrinology Laboratory, Florey Institute of 
      Neuroscience & Mental Health, VIC, Australia.
FAU - Hill, Rachel
AU  - Hill R
AD  - Behavioural Neuroscience Laboratory, Florey Institute of Neuroscience & Mental 
      Health, VIC, Australia; Psychoneuroendocrinology Laboratory, Florey Institute of 
      Neuroscience & Mental Health, VIC, Australia.
FAU - van den Buuse, Maarten
AU  - van den Buuse M
AD  - Behavioural Neuroscience Laboratory, Florey Institute of Neuroscience & Mental 
      Health, VIC, Australia; Department of Pharmacology & Therapeutics, University of 
      Melbourne, VIC, Australia; School of Psychological Science, La Trobe University, 
      VIC, Australia. Electronic address: m.vandenbuuse@latrobe.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150103
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Animals
MH  - Brain/pathology/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Schizophrenia/*genetics/pathology/physiopathology
OTO - NOTNLM
OT  - Age of onset
OT  - Animal models of schizophrenia
OT  - BDNF
OT  - Brain morphology
OT  - Brain-derived neurotrophic factor
OT  - Clinical pleiotropy
OT  - Cognition
OT  - Comorbid symptoms
OT  - G196A
OT  - Psychosis
OT  - Schizophrenia
OT  - Therapeutic responsiveness
OT  - Val66Met
OT  - Val66Met mice
OT  - rs6265
EDAT- 2015/01/07 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/01/07 06:00
PHST- 2014/05/22 00:00 [received]
PHST- 2014/11/14 00:00 [revised]
PHST- 2014/12/27 00:00 [accepted]
PHST- 2015/01/07 06:00 [entrez]
PHST- 2015/01/07 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0149-7634(14)00355-8 [pii]
AID - 10.1016/j.neubiorev.2014.12.016 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2015 Apr;51:15-30. doi: 10.1016/j.neubiorev.2014.12.016. 
      Epub 2015 Jan 3.