PMID- 25563380
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0028-2685 (Print)
IS  - 0028-2685 (Linking)
VI  - 62
IP  - 1
DP  - 2015
TI  - GROalpha expression and its prognostic implications in laryngeal squamous cell 
      carcinoma.
PG  - 152-8
AB  - The growth-regulated oncogene alpha (GROalpha) , which is also designated as CXC 
      chemokine ligand 1 (CXCL1), was first identified as an autocrine growth factor in 
      human malignant melanoma. It is involved in tumor development and invasion, and 
      is highly expressed in various human cancers. However, little is known about the 
      association between GROalpha expression and the clinical attributes of laryngeal 
      squamous cell carcinoma (LSCC). One-step quantitative reverse 
      transcription-polymerase chain reaction (qRT-PCR) and immunohistochemical 
      staining of tissue microarrays were employed to evaluate the relationship between 
      GROalpha expression and LSCC clinicopathological attributes. GROalpha mRNA and protein 
      expression levels were significantly greater in LSCC than in non-cancerous 
      tumor-adjacent tissues. GROalpha protein expression in LSCC was also significantly 
      associated with TNM stage, lymph node metastasis, and histopathological grade. 
      Kaplan-Meier and Cox multi-factor analyses suggested that increased GROalpha 
      expression and positive lymph node metastasis were significantly associated with 
      the poor survival of LSCC patients. These data indicate that GROalpha may be a novel 
      prognostic marker of LSCC. KEYWORDS: GROalpha,LSCC,qPCR,immunohistochemistry, 
      prognosis.
FAU - Han, L
AU  - Han L
FAU - Liu, W
AU  - Liu W
FAU - Chen, Y
AU  - Chen Y
FAU - Wu, H
AU  - Wu H
FAU - Zhang, Y
AU  - Zhang Y
FAU - Jiang, B
AU  - Jiang B
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Neoplasma
JT  - Neoplasma
JID - 0377266
SB  - IM
EDAT- 2015/01/08 06:00
MHDA- 2015/01/08 06:01
CRDT- 2015/01/08 06:00
PHST- 2015/01/08 06:00 [entrez]
PHST- 2015/01/08 06:00 [pubmed]
PHST- 2015/01/08 06:01 [medline]
AID - 10.4149/neo_2015_020 [doi]
PST - ppublish
SO  - Neoplasma. 2015;62(1):152-8. doi: 10.4149/neo_2015_020.