PMID- 25563785
OWN - NLM
STAT- MEDLINE
DCOM- 20150702
LR  - 20181202
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 159
DP  - 2015
TI  - [A paradox: sarcoidosis in an HIV-positive patient].
PG  - A8353
AB  - BACKGROUND: In view of the diminished number of CD4+ lymphocytes, the 
      co-existence of an HIV infection and sarcoidosis seems paradoxical. Immune 
      reconstitution inflammatory syndrome (IRIS) may be observed in response to 
      anti-retroviral therapy (ART). According to the conventional definition, this is 
      caused by an overwhelming immune response to an already present or to a new 
      agent. CASE DESCRIPTION: We describe the case of a 47-year-old HIV-positive 
      patient, who presented with an exacerbation of his sarcoidosis nine months after 
      initiation of ART. Based on the time course and the dynamics of the CD4+ 
      lymphocyte count, this presentation of disease can be placed in the context of 
      IRIS. CONCLUSION: The presentation or exacerbation of sarcoidosis after 
      initiation of antiretroviral therapy in HIV-positive patients with a low CD4+ 
      count at start of therapy can be placed in the context of IRIS.
FAU - van Kan, Coen
AU  - van Kan C
AD  - Onze Lieve Vrouwe Gasthuis, Amsterdam.
FAU - Peringa, Jan
AU  - Peringa J
FAU - Walter, Armin W
AU  - Walter AW
FAU - Frissen, P H J Jos
AU  - Frissen PH
FAU - Bresser, Paul
AU  - Bresser P
LA  - dut
PT  - Case Reports
PT  - Journal Article
TT  - Een paradox: sarcoidose bij een hiv-positieve patient.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
MH  - Antiretroviral Therapy, Highly Active
MH  - *CD4 Lymphocyte Count
MH  - HIV Infections/*epidemiology/immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Sarcoidosis/*epidemiology/immunology
EDAT- 2015/01/08 06:00
MHDA- 2015/07/03 06:00
CRDT- 2015/01/08 06:00
PHST- 2015/01/08 06:00 [entrez]
PHST- 2015/01/08 06:00 [pubmed]
PHST- 2015/07/03 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2015;159:A8353.