PMID- 25564266
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20181202
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 22
IP  - 3
DP  - 2015 Mar
TI  - Association between matrix metalloproteinase-3 gene polymorphism and moyamoya 
      disease.
PG  - 479-82
LID - S0967-5868(14)00626-2 [pii]
LID - 10.1016/j.jocn.2014.08.034 [doi]
AB  - Genetic factors play an important role in the etiology and pathogenesis of 
      moyamoya disease (MMD). Recently, several studies suggested the decreased 
      expression of matrix metalloproteinase-3 (MMP3) was associated with an increased 
      risk of MMD. This case-control study was performed to examine the association 
      between MMP3 polymorphisms and the risk of MMD, comparing 86 Han Chinese MMD 
      patients and 86 controls. We further conducted a meta-analysis, combining our 
      results with all previous studies to provide a more precise estimate of this 
      association. In our case-control study, MMP3 6A/6A (odds ratio [OR]=1.93, 95% 
      confidence interval [CI] 1.00-3.72; p=0.05) and 6A allele frequencies (OR=1.78, 
      95%CI 1.00-3.14; p=0.05) in the MMD group were significantly higher than those in 
      the control group. In the additional meta-analysis, only two other studies were 
      identified. Meta-analysis with a total of 796 patients revealed 6A allele and 
      6A/6A genotype significantly increased the risk of MMD (OR=1.64, 95% CI 
      1.26-2.13, p=0.0002 and OR=1.79, 95% CI 1.32-2.42, p=0.0002, respectively). To 
      confirm this finding, an additional analysis should be performed using a larger 
      sample size. Moreover, larger and well-designed multicentric studies based on 
      different races should be performed to evaluate the racial difference.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Ma, Junpeng
AU  - Ma J
AD  - Department of Neurosurgery, West China Hospital, Sichuan University, 37 
      Guoxuexiang Street, Chengdu 610041, China.
FAU - You, Chao
AU  - You C
AD  - Department of Neurosurgery, West China Hospital, Sichuan University, 37 
      Guoxuexiang Street, Chengdu 610041, China. Electronic address: 
      youchao028@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20150103
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Moyamoya Disease/*genetics
MH  - Odds Ratio
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Risk
MH  - Sequence Analysis, DNA
OTO - NOTNLM
OT  - MMP
OT  - Moyamoya disease
OT  - Polymorphisms
EDAT- 2015/01/08 06:00
MHDA- 2016/04/19 06:00
CRDT- 2015/01/08 06:00
PHST- 2014/07/01 00:00 [received]
PHST- 2014/08/23 00:00 [revised]
PHST- 2014/08/30 00:00 [accepted]
PHST- 2015/01/08 06:00 [entrez]
PHST- 2015/01/08 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
AID - S0967-5868(14)00626-2 [pii]
AID - 10.1016/j.jocn.2014.08.034 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2015 Mar;22(3):479-82. doi: 10.1016/j.jocn.2014.08.034. Epub 
      2015 Jan 3.