PMID- 25564633
OWN - NLM
STAT- MEDLINE
DCOM- 20150921
LR  - 20190201
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2015
DP  - 2015 Jan 6
TI  - Late onset of cryptococcal cervical lymphadenitis following immune reconstitution 
      inflammatory syndrome in a patient with AIDS.
LID - 10.1136/bcr-2014-206601 [doi]
LID - bcr2014206601
AB  - A 32-year-old woman was diagnosed HIV positive with disseminated cryptococcal 
      infection in May 2006. Her initial CD4 was 7 cells/microL and she had a right 
      supraclavicular nodal mass, which was biopsied and shown to be consistent with 
      cryptococcal lymphadenitis. She was treated for disseminated cryptococcal 
      infection and was started on antiretroviral medications subsequently. Two years 
      later, she developed a left supraclavicular mass. Her CD4 count was 320 cells/microL 
      and HIV RNA level was undetectable. Investigations and biopsy results were 
      consistent with a late presentation of cryptococcal immune reconstitution 
      inflammatory syndrome (IRIS). She was treated with oral corticosteroids and her 
      symptoms resolved completely. IRIS is a recognised complication of HIV treatment 
      and occurs in a significant percentage of patients within the first 3 months of 
      starting antiretroviral therapy. This case report illustrates the importance of 
      recognising late presentations of IRIS. It is vital to differentiate true 
      cryptococcal lymphadenitis from IRIS-induced cryptococcal lymphadenitis.
CI  - 2015 BMJ Publishing Group Ltd.
FAU - Sethupathi, Meenakshi
AU  - Sethupathi M
AD  - Department of GUM/HIV, Betsi Cadwaladr University Health Board, Bangor, UK.
FAU - Yoganathan, Kathir
AU  - Yoganathan K
AD  - Department of Genito-Urinary and HIV Medicine, Abertawe Bro Morgannwg University 
      Health Board, Singleton Hospital, Swansea, South Wales, UK.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150106
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*drug therapy
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Adult
MH  - Anti-HIV Agents/*adverse effects
MH  - Cryptococcosis/*complications
MH  - Female
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/chemically induced/drug 
      therapy/*microbiology
MH  - Lymphadenitis/*microbiology
MH  - Neck
PMC - PMC4289790
EDAT- 2015/01/08 06:00
MHDA- 2015/09/22 06:00
PMCR- 2017/01/06
CRDT- 2015/01/08 06:00
PHST- 2015/01/08 06:00 [entrez]
PHST- 2015/01/08 06:00 [pubmed]
PHST- 2015/09/22 06:00 [medline]
PHST- 2017/01/06 00:00 [pmc-release]
AID - bcr-2014-206601 [pii]
AID - 10.1136/bcr-2014-206601 [doi]
PST - epublish
SO  - BMJ Case Rep. 2015 Jan 6;2015:bcr2014206601. doi: 10.1136/bcr-2014-206601.