PMID- 2556484
OWN - NLM
STAT- MEDLINE
DCOM- 19900122
LR  - 20071115
IS  - 0392-9590 (Print)
IS  - 0392-9590 (Linking)
VI  - 8
IP  - 3
DP  - 1989 Jul-Sep
TI  - Low molecular weight heparin (Alfa LHWH) compared with unfractionated heparin in 
      prevention of deep-vein thrombosis after hip fractures.
PG  - 134-9
AB  - Efficacy and safety of a low molecular weight heparin (Alfa LMWH) was compared 
      with unfractionated heparin (UFH) in the prevention of post-operative venous 
      thromboembolism after hip fractures. Forty-nine patients were randomized to 
      treatment with Alfa LMWH 7500 anti-Xa coagulometric units twice daily or with UFH 
      5000 IU t.i.d. Screening for thrombosis was performed with 125-I-fibrinogen leg 
      scanning and strain-gauge plethysmography. Positive results were confirmed by 
      venography. Five patients in the Alfa LMWH group (20 per cent) developed 
      venographycally proven deep vein thrombosis (DVT) versus seven (29 per cent) in 
      the UFH group. One pulmonary embolism and two deaths occurred in the UFH group 
      and none in the LMWH group. No differences in haemorrhagic complications and 
      blood loss indices were observed. Alfa LMWH appears to be a promising drug for 
      prevention of venous thromboembolism after orthopaedic surgery. A "flexible" 
      schedule of administration is proposed on the basis of the results of plasma 
      anti-Xa assays.
FAU - Pini, M
AU  - Pini M
AD  - Vth Medical Department, Ospedale Maggiore, Parma, Italy.
FAU - Tagliaferri, A
AU  - Tagliaferri A
FAU - Manotti, C
AU  - Manotti C
FAU - Lasagni, F
AU  - Lasagni F
FAU - Rinaldi, E
AU  - Rinaldi E
FAU - Dettori, A G
AU  - Dettori AG
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Italy
TA  - Int Angiol
JT  - International angiology : a journal of the International Union of Angiology
JID - 8402693
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Coagulation Tests
MH  - Female
MH  - Heparin/*administration & dosage/adverse effects
MH  - Heparin, Low-Molecular-Weight/*administration & dosage/adverse effects
MH  - Hip Fractures/*surgery
MH  - Humans
MH  - Male
MH  - Postoperative Complications/*prevention & control
MH  - Randomized Controlled Trials as Topic
MH  - Thrombophlebitis/*prevention & control
EDAT- 1989/07/01 00:00
MHDA- 1989/07/01 00:01
CRDT- 1989/07/01 00:00
PHST- 1989/07/01 00:00 [pubmed]
PHST- 1989/07/01 00:01 [medline]
PHST- 1989/07/01 00:00 [entrez]
PST - ppublish
SO  - Int Angiol. 1989 Jul-Sep;8(3):134-9.