PMID- 25565964
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150108
LR  - 20230921
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 8
DP  - 2014
TI  - Brain-derived neurotrophic factor: a bridge between inflammation and 
      neuroplasticity.
PG  - 430
LID - 10.3389/fncel.2014.00430 [doi]
LID - 430
AB  - Cytokines are key regulatory mediators involved in the host response to 
      immunological challenges, but also play a critical role in the communication 
      between the immune and the central nervous system. For this, their expression in 
      both systems is under a tight regulatory control. However, pathological 
      conditions may lead to an overproduction of pro-inflammatory cytokines that may 
      have a detrimental impact on central nervous system. In particular, they may 
      damage neuronal structure and function leading to deficits of neuroplasticity, 
      the ability of nervous system to perceive, respond and adapt to external or 
      internal stimuli. In search of the mechanisms by which pro-inflammatory cytokines 
      may affect this crucial brain capability, we will discuss one of the most 
      interesting hypotheses: the involvement of the neurotrophin brain-derived 
      neurotrophic factor (BDNF), which represents one of the major mediators of 
      neuroplasticity.
FAU - Calabrese, Francesca
AU  - Calabrese F
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano Milan, Italy.
FAU - Rossetti, Andrea C
AU  - Rossetti AC
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano Milan, Italy.
FAU - Racagni, Giorgio
AU  - Racagni G
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano Milan, Italy.
FAU - Gass, Peter
AU  - Gass P
AD  - Department of Psychiatry and Psychotherapy, Research Group Animal Models in 
      Psychiatry, Central Institute of Mental Health, Medical Faculty 
      Mannheim/Heidelberg University Mannheim, Germany.
FAU - Riva, Marco A
AU  - Riva MA
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano Milan, Italy.
FAU - Molteni, Raffaella
AU  - Molteni R
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141222
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC4273623
OTO - NOTNLM
OT  - BDNF
OT  - depression
OT  - lipopolysaccaride
OT  - neurogenesis
OT  - pro-inflammatory cytokines
EDAT- 2015/01/08 06:00
MHDA- 2015/01/08 06:01
PMCR- 2014/01/01
CRDT- 2015/01/08 06:00
PHST- 2014/09/30 00:00 [received]
PHST- 2014/11/29 00:00 [accepted]
PHST- 2015/01/08 06:00 [entrez]
PHST- 2015/01/08 06:00 [pubmed]
PHST- 2015/01/08 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2014.00430 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2014 Dec 22;8:430. doi: 10.3389/fncel.2014.00430. 
      eCollection 2014.