PMID- 25566019
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150108
LR  - 20220409
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 8
DP  - 2014
TI  - BDNF mediates improvements in executive function following a 1-year exercise 
      intervention.
PG  - 985
LID - 10.3389/fnhum.2014.00985 [doi]
LID - 985
AB  - Executive function declines with age, but engaging in aerobic exercise may 
      attenuate decline. One mechanism by which aerobic exercise may preserve executive 
      function is through the up-regulation of brain-derived neurotropic factor (BDNF), 
      which also declines with age. The present study examined BDNF as a mediator of 
      the effects of a 1-year walking intervention on executive function in 90 older 
      adults (mean age = 66.82). Participants were randomized to a stretching and 
      toning control group or a moderate intensity walking intervention group. BDNF 
      serum levels and performance on a task-switching paradigm were collected at 
      baseline and follow-up. We found that age moderated the effect of intervention 
      group on changes in BDNF levels, with those in the highest age quartile showing 
      the greatest increase in BDNF after 1-year of moderate intensity walking exercise 
      (p = 0.036). The mediation analyses revealed that BDNF mediated the effect of the 
      intervention on task-switch accuracy, but did so as a function of age, such that 
      exercise-induced changes in BDNF mediated the effect of exercise on task-switch 
      performance only for individuals over the age of 71. These results demonstrate 
      that both age and BDNF serum levels are important factors to consider when 
      investigating the mechanisms by which exercise interventions influence cognitive 
      outcomes, particularly in elderly populations.
FAU - Leckie, Regina L
AU  - Leckie RL
AD  - Department of Psychology, University of Pittsburgh Pittsburgh, PA, USA ; Center 
      for the Neural Basis of Cognition, University of Pittsburgh Pittsburgh, PA, USA.
FAU - Oberlin, Lauren E
AU  - Oberlin LE
AD  - Department of Psychology, University of Pittsburgh Pittsburgh, PA, USA ; Center 
      for the Neural Basis of Cognition, University of Pittsburgh Pittsburgh, PA, USA.
FAU - Voss, Michelle W
AU  - Voss MW
AD  - Department of Psychology, University of Iowa Iowa City, IA, USA.
FAU - Prakash, Ruchika S
AU  - Prakash RS
AD  - Department of Psychology, Ohio State University Columbus, OH, USA.
FAU - Szabo-Reed, Amanda
AU  - Szabo-Reed A
AD  - Cardiovascular Research Institute, University of Kansas Medical Center Kansas 
      City, KS, USA.
FAU - Chaddock-Heyman, Laura
AU  - Chaddock-Heyman L
AD  - Beckman Institute for Advanced Science and Technology, University of Illinois 
      Champaign-Urbana, IL, USA.
FAU - Phillips, Siobhan M
AU  - Phillips SM
AD  - Department of Preventative Medicine, Northwestern University Medical School 
      Chicago, IL, USA.
FAU - Gothe, Neha P
AU  - Gothe NP
AD  - Department of Kinesiology, Wayne State University Detroit, MI, USA.
FAU - Mailey, Emily
AU  - Mailey E
AD  - Department of Kinesiology, Kansas State University Manhattan, KS, USA.
FAU - Vieira-Potter, Victoria J
AU  - Vieira-Potter VJ
AD  - Department of Kinesiology and Community Health, University of Illinois 
      Champaign-Urbana, IL, USA.
FAU - Martin, Stephen A
AU  - Martin SA
AD  - Department of Kinesiology and Community Health, University of Illinois 
      Champaign-Urbana, IL, USA.
FAU - Pence, Brandt D
AU  - Pence BD
AD  - Department of Kinesiology and Community Health, University of Illinois 
      Champaign-Urbana, IL, USA.
FAU - Lin, Mingkuan
AU  - Lin M
AD  - Department of Neuroscience, George Mason University Fairfax, VA, USA.
FAU - Parasuraman, Raja
AU  - Parasuraman R
AD  - Department of Psychology, George Mason University Fairfax, VA, USA.
FAU - Greenwood, Pamela M
AU  - Greenwood PM
AD  - Department of Psychology, George Mason University Fairfax, VA, USA.
FAU - Fryxell, Karl J
AU  - Fryxell KJ
AD  - School of Molecular Biology, George Mason University Fairfax, VA, USA.
FAU - Woods, Jeffrey A
AU  - Woods JA
AD  - Department of Kinesiology and Community Health, University of Illinois 
      Champaign-Urbana, IL, USA.
FAU - McAuley, Edward
AU  - McAuley E
AD  - Beckman Institute for Advanced Science and Technology, University of Illinois 
      Champaign-Urbana, IL, USA ; Department of Kinesiology and Community Health, 
      University of Illinois Champaign-Urbana, IL, USA.
FAU - Kramer, Arthur F
AU  - Kramer AF
AD  - Beckman Institute for Advanced Science and Technology, University of Illinois 
      Champaign-Urbana, IL, USA.
FAU - Erickson, Kirk I
AU  - Erickson KI
AD  - Department of Psychology, University of Pittsburgh Pittsburgh, PA, USA ; Center 
      for the Neural Basis of Cognition, University of Pittsburgh Pittsburgh, PA, USA ; 
      Center for Neuroscience, University of Pittsburgh Pittsburgh, PA, USA.
LA  - eng
GR  - F32 DK103493/DK/NIDDK NIH HHS/United States
GR  - R01 DK095172/DK/NIDDK NIH HHS/United States
GR  - T32 GM081760/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20141211
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC4263078
OTO - NOTNLM
OT  - BDNF
OT  - aging
OT  - cognition
OT  - executive function
OT  - exercise
OT  - mediation analysis
OT  - physical activity
EDAT- 2015/01/08 06:00
MHDA- 2015/01/08 06:01
PMCR- 2014/01/01
CRDT- 2015/01/08 06:00
PHST- 2014/08/05 00:00 [received]
PHST- 2014/11/18 00:00 [accepted]
PHST- 2015/01/08 06:00 [entrez]
PHST- 2015/01/08 06:00 [pubmed]
PHST- 2015/01/08 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2014.00985 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2014 Dec 11;8:985. doi: 10.3389/fnhum.2014.00985. eCollection 
      2014.