PMID- 25566258
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150108
LR  - 20220317
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 5
DP  - 2014
TI  - Dendritic cells in dengue virus infection: targets of virus replication and 
      mediators of immunity.
PG  - 647
LID - 10.3389/fimmu.2014.00647 [doi]
LID - 647
AB  - Dendritic cells (DCs) are sentinels of the immune system and detect pathogens at 
      sites of entry, such as the skin. In addition to the ability of DCs to control 
      infections directly via their innate immune functions, DCs help to prime adaptive 
      B- and T-cell responses by processing and presenting antigen in lymphoid tissues. 
      Infected Aedes aegypti or Aedes albopictus mosquitoes transmit the four dengue 
      virus (DENV) serotypes to humans while probing for small blood vessels in the 
      skin. DENV causes the most prevalent arthropod-borne viral disease in humans, yet 
      no vaccine or specific therapeutic is currently licensed. Although primary DENV 
      infection confers life-long protective immunity against re-infection with the 
      same DENV serotype, secondary infection with a different DENV serotype can lead 
      to increased disease severity via cross-reactive T-cells or enhancing antibodies. 
      This review summarizes recent findings in humans and animal models about DENV 
      infection of DCs, monocytes, and macrophages. We discuss the dual role of DCs as 
      both targets of DENV replication and mediators of innate and adaptive immunity, 
      and summarize immune evasion strategies whereby DENV impairs the function of 
      infected DCs. We suggest that DCs play a key role in priming DENV-specific 
      neutralizing or potentially harmful memory B- and T-cell responses, and that 
      future DC-directed therapies may help induce protective memory responses and 
      reduce dengue pathogenesis.
FAU - Schmid, Michael A
AU  - Schmid MA
AD  - Division of Infectious Diseases and Vaccinology, School of Public Health, 
      University of California Berkeley , Berkeley, CA , USA.
FAU - Diamond, Michael S
AU  - Diamond MS
AD  - Department of Medicine, Washington University School of Medicine , St. Louis, MO 
      , USA ; Department of Molecular Microbiology, Washington University School of 
      Medicine , St. Louis, MO , USA ; Department of Pathology and Immunology, 
      Washington University School of Medicine , St. Louis, MO , USA.
FAU - Harris, Eva
AU  - Harris E
AD  - Division of Infectious Diseases and Vaccinology, School of Public Health, 
      University of California Berkeley , Berkeley, CA , USA.
LA  - eng
GR  - R01 AI085607/AI/NIAID NIH HHS/United States
GR  - U01 AI077955/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20141217
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC4269190
OTO - NOTNLM
OT  - antibody-dependent enhancement
OT  - dendritic cells
OT  - dengue virus
OT  - immune evasion
OT  - innate immunity
OT  - macrophages
OT  - monocytes
EDAT- 2015/01/08 06:00
MHDA- 2015/01/08 06:01
PMCR- 2014/01/01
CRDT- 2015/01/08 06:00
PHST- 2014/10/09 00:00 [received]
PHST- 2014/12/04 00:00 [accepted]
PHST- 2015/01/08 06:00 [entrez]
PHST- 2015/01/08 06:00 [pubmed]
PHST- 2015/01/08 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2014.00647 [doi]
PST - epublish
SO  - Front Immunol. 2014 Dec 17;5:647. doi: 10.3389/fimmu.2014.00647. eCollection 
      2014.