PMID- 25566459
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150108
LR  - 20200929
IS  - 2233-6834 (Print)
IS  - 2233-6842 (Electronic)
IS  - 2233-6834 (Linking)
VI  - 18
IP  - 2
DP  - 2014 Jun
TI  - The effect of treadmill exercise on inflammatory responses in rat model of 
      streptozotocin-induced experimental dementia of Alzheimer's type.
PG  - 225-33
LID - 10.5717/jenb.2014.18.2.225 [doi]
AB  - PURPOSE: The aim of this study was to investigate the effect of treadmill 
      exercise on inflammatory response in streptozotocin (STZ)-induced animal model of 
      Alzheimer's disease (AD). METHODS: To induce the animal model of AD, 
      Sprague-Dawley rats were injected into intracerebroventricular (ICV) injection 
      with 1.5 mg/kg of STZ. Rats were divided into three groups as Sham-con group (n = 
      7), STZ-con group (n = 7) and STZ-exe group (n = 7). Exercise group ran on the 
      treadmill for 30 min/day, 5 days/week during 6 weeks. RESULTS: The results of 
      this study were as follows: First, STZ-exe group was improved on cognitive 
      function when compared to STZ-con group in water maze test. Second, STZ-exe group 
      help reduce the expression level of amyloid-beta (Abeta). In addition, Toll-like 
      receptors-4 (TLR4), Nuclear factor-kB (NF-kB), Tumor necrosis factor-alpha (TNF-alpha) 
      and Interleukin-1alpha (IL-1alpha) level of STZ-exe group was significantly decreased 
      when compared to STZ-con group. CONCLUSION: These results show that treadmill 
      exercise had positive effect on cognitive function and reduced inflammatory 
      response in STZ-induced animal model of AD.
FAU - Choi, Dong Hun
AU  - Choi DH
AD  - Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, 
      Songpa-gu, Seoul, 138-763, Korea.
FAU - Kwon, In Su
AU  - Kwon IS
AD  - Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, 
      Songpa-gu, Seoul, 138-763, Korea.
FAU - Koo, Jung Hoon
AU  - Koo JH
AD  - Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, 
      Songpa-gu, Seoul, 138-763, Korea.
FAU - Jang, Yong Chul
AU  - Jang YC
AD  - Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, 
      Songpa-gu, Seoul, 138-763, Korea.
FAU - Kang, Eun Bum
AU  - Kang EB
AD  - Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, 
      Songpa-gu, Seoul, 138-763, Korea.
FAU - Byun, Jung Eun
AU  - Byun JE
AD  - Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, 
      Songpa-gu, Seoul, 138-763, Korea.
FAU - Um, Hyun Sub
AU  - Um HS
AD  - Department of exercise prescription, Kon-Yang University, 121 Daehak-ro, Nosan 
      chugnam 320-711, Korea.
FAU - Park, Hoo Seong
AU  - Park HS
AD  - Department of physical education, Chosun University, 309 Pilmun-daero Dong-gu 
      Gwangju 501-759, Korea.
FAU - Yeom, Dong Cheol
AU  - Yeom DC
AD  - Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, 
      Songpa-gu, Seoul, 138-763, Korea.
FAU - Cho, In Ho
AU  - Cho IH
AD  - Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, 
      Songpa-gu, Seoul, 138-763, Korea.
FAU - Cho, Joon Yong
AU  - Cho JY
AD  - Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, 
      Songpa-gu, Seoul, 138-763, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140215
PL  - Korea (South)
TA  - J Exerc Nutrition Biochem
JT  - Journal of exercise nutrition & biochemistry
JID - 101572566
PMC - PMC4241920
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Amyloid-beta
OT  - Inflammatory
OT  - Streptozotocin
OT  - Treadmill exercise
EDAT- 2015/01/08 06:00
MHDA- 2015/01/08 06:01
PMCR- 2014/06/01
CRDT- 2015/01/08 06:00
PHST- 2014/01/16 00:00 [received]
PHST- 2014/02/10 00:00 [revised]
PHST- 2014/02/15 00:00 [accepted]
PHST- 2015/01/08 06:00 [entrez]
PHST- 2015/01/08 06:00 [pubmed]
PHST- 2015/01/08 06:01 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - jenb-18-2-225 [pii]
AID - 10.5717/jenb.2014.18.2.225 [doi]
PST - ppublish
SO  - J Exerc Nutrition Biochem. 2014 Jun;18(2):225-33. doi: 
      10.5717/jenb.2014.18.2.225. Epub 2014 Feb 15.