PMID- 25566514
OWN - NLM
STAT- MEDLINE
DCOM- 20150715
LR  - 20181113
IS  - 2235-2988 (Electronic)
IS  - 2235-2988 (Linking)
VI  - 4
DP  - 2014
TI  - Myeloid decidual dendritic cells and immunoregulation of pregnancy: defective 
      responsiveness to Coxiella burnetii and Brucella abortus.
PG  - 179
LID - 10.3389/fcimb.2014.00179 [doi]
LID - 179
AB  - Dendritic cells (DCs) are a component of the placental immune system, but their 
      role in pregnancy is still poorly understood. Decidual DCs (dDCs) were selected 
      from at-term pregnancy on the basis of CD14 and CD11c expression. A phenotypic 
      analysis revealed that dDCs are characterized by the expression of 
      monocyte-derived DC (moDCs) markers and specific markers such as HLA-G and its 
      ligand ILT4. As demonstrated by whole-genome microarray, dDCs expressed a 
      specific gene program markedly distinct from that of moDCs; it included estrogen- 
      and progesterone-regulated genes and genes encoding immunoregulatory cytokines, 
      which is consistent with the context of foeto-maternal tolerance. A functional 
      analysis of dDCs showed that they were unable to mature in response to bacterial 
      ligands such as lipopolysaccharide or peptidoglycan, as assessed by the 
      expression of HLA-DR, CD80, CD83, and CD86. When dDCs were incubated with 
      bacteria known for their placenta tropism, Coxiella burnetii and Brucella 
      abortus, they were also unable to mature and to produce inflammatory cytokines. 
      It is likely that the defective maturation of dDCs and their inability to produce 
      inflammatory cytokines is related to the spontaneous release of IL-10 by these 
      cells. Taken together, these results suggest that dDCs exhibit an 
      immunoregulatory program, which may favor the pathogenicity of C. burnetii or B. 
      abortus.
FAU - Gorvel, Laurent
AU  - Gorvel L
AD  - CNRS UMR 7278, IRD198, INSERM U1095, Unite de Recherche sur les Maladies 
      Infectieuses Tropicales Emergentes (URMITE), Aix-Marseille University Marseille, 
      France.
FAU - Ben Amara, Amira
AU  - Ben Amara A
AD  - CNRS UMR 7278, IRD198, INSERM U1095, Unite de Recherche sur les Maladies 
      Infectieuses Tropicales Emergentes (URMITE), Aix-Marseille University Marseille, 
      France.
FAU - Ka, Mignane B
AU  - Ka MB
AD  - CNRS UMR 7278, IRD198, INSERM U1095, Unite de Recherche sur les Maladies 
      Infectieuses Tropicales Emergentes (URMITE), Aix-Marseille University Marseille, 
      France.
FAU - Textoris, Julien
AU  - Textoris J
AD  - CNRS UMR 7278, IRD198, INSERM U1095, Unite de Recherche sur les Maladies 
      Infectieuses Tropicales Emergentes (URMITE), Aix-Marseille University Marseille, 
      France.
FAU - Gorvel, Jean-Pierre
AU  - Gorvel JP
AD  - UM2, INSERM U1104, CNRS, UMR7280, Centre d'Immunologie de Marseille Luminy, 
      Aix-Marseille University Marseille, France.
FAU - Mege, Jean-Louis
AU  - Mege JL
AD  - CNRS UMR 7278, IRD198, INSERM U1095, Unite de Recherche sur les Maladies 
      Infectieuses Tropicales Emergentes (URMITE), Aix-Marseille University Marseille, 
      France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141223
PL  - Switzerland
TA  - Front Cell Infect Microbiol
JT  - Frontiers in cellular and infection microbiology
JID - 101585359
SB  - IM
MH  - Adult
MH  - Brucella abortus/*immunology/physiology
MH  - Brucellosis/*immunology/microbiology
MH  - Cells, Cultured
MH  - Coxiella burnetii/*immunology/physiology
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Humans
MH  - Monocytes/*immunology
MH  - Placenta/immunology/microbiology
MH  - Pregnancy
MH  - Pregnancy Complications/*immunology/microbiology
MH  - Q Fever/*immunology/microbiology
PMC - PMC4275036
OTO - NOTNLM
OT  - dendritic cell
OT  - immunoregulation
OT  - microarray
OT  - phenotype
OT  - placenta
EDAT- 2015/01/08 06:00
MHDA- 2015/07/16 06:00
PMCR- 2014/01/01
CRDT- 2015/01/08 06:00
PHST- 2014/10/29 00:00 [received]
PHST- 2014/12/05 00:00 [accepted]
PHST- 2015/01/08 06:00 [entrez]
PHST- 2015/01/08 06:00 [pubmed]
PHST- 2015/07/16 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fcimb.2014.00179 [doi]
PST - epublish
SO  - Front Cell Infect Microbiol. 2014 Dec 23;4:179. doi: 10.3389/fcimb.2014.00179. 
      eCollection 2014.