PMID- 25566858
OWN - NLM
STAT- MEDLINE
DCOM- 20150508
LR  - 20220331
IS  - 0895-3988 (Print)
IS  - 0895-3988 (Linking)
VI  - 28
IP  - 1
DP  - 2015 Jan
TI  - In vitro and in vivo evaluation of the developed PLGA/HAp/Zein scaffolds for 
      bone-cartilage interface regeneration.
PG  - 1-12
LID - 10.3967/bes2015.001 [doi]
AB  - OBJECTIVE: To investigate the effect of electronspun PLGA/HAp/Zein scaffolds on 
      the repair of cartilage defects. METHODS: The PLGA/HAp/Zein composite scaffolds 
      were fabricated by electrospinning method. The physiochemical properties and 
      biocompatibility of the scaffolds were separately characterized by scanning 
      electron microscope (SEM), transmission electron microscope (TEM), and fourier 
      transform infrared spectroscopy (FTIR), human umbilical cord mesenchymal stem 
      cells (hUC-MSCs) culture and animal experiments. RESULTS: The prepared 
      PLGA/HAp/Zein scaffolds showed fibrous structure with homogenous distribution. 
      hUC-MSCs could attach to and grow well on PLGA/HAp/Zein scaffolds, and there was 
      no significant difference between cell proliferation on scaffolds and that 
      without scaffolds (P>0.05). The PLGA/HAp/Zein scaffolds possessed excellent 
      ability to promote in vivo cartilage formation. Moreover, there was a large 
      amount of immature chondrocytes and matrix with cartilage lacuna on PLGA/HAp/Zein 
      scaffolds. CONCLUSION: The data suggest that the PLGA/HAp/Zein scaffolds possess 
      good biocompatibility, which are anticipated to be potentially applied in 
      cartilage tissue engineering and reconstruction.
CI  - Copyright (c) 2015 The Editorial Board of Biomedical and Environmental Sciences. 
      Published by China CDC. All rights reserved.
FAU - Lin, Yong Xin
AU  - Lin YX
AD  - Department of Orthopedics, the First Affiliated Hospital of Jinan University, 
      Guangzhou 510630, Guangdong, China.
FAU - Ding, Zhi Yong
AU  - Ding ZY
AD  - Department of Traumatology, HuiZhou Municipal Central Hospital, Huizhou 516000, 
      Guangdong, China.
FAU - Zhou, Xiao Bin
AU  - Zhou XB
AD  - Department of Orthopedics, the First Affiliated Hospital of Jinan University, 
      Guangzhou 510630, Guangdong, China.
FAU - Li, Si Tao
AU  - Li ST
AD  - Department of Pediatrics, the Sixth Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou 510655, Guangdong, China.
FAU - Xie, De Ming
AU  - Xie de M
AD  - Department of Biomedical Engineering, College of Life Science and Technology, 
      Jinan University, Guangzhou 510630, Guangdong, China.
FAU - Li, Zhi Zhong
AU  - Li ZZ
AD  - Department of Orthopedics, the First Affiliated Hospital of Jinan University, 
      Guangzhou 510630, Guangdong, China.
FAU - Sun, Guo Dong
AU  - Sun GD
AD  - Department of Orthopedics, the First Affiliated Hospital of Jinan University, 
      Guangzhou 510630, Guangdong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Biomed Environ Sci
JT  - Biomedical and environmental sciences : BES
JID - 8909524
RN  - 0 (Biocompatible Materials)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9010-66-6 (Zein)
RN  - 91D9GV0Z28 (Durapatite)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials
MH  - Bone Development/*physiology
MH  - Cartilage/*growth & development
MH  - Cells, Cultured
MH  - Durapatite/*chemistry
MH  - Female
MH  - Humans
MH  - Lactic Acid/*chemistry
MH  - Male
MH  - Mesenchymal Stem Cells/physiology
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Regeneration/physiology
MH  - Tissue Scaffolds/*chemistry
MH  - Young Adult
MH  - Zein/*chemistry
OTO - NOTNLM
OT  - Cartilage tissue engineering
OT  - Chondrocyte
OT  - Electrospun
OT  - PLGA/HAp/Zein grafts
OT  - hUC-MSCs
EDAT- 2015/01/09 06:00
MHDA- 2015/05/09 06:00
CRDT- 2015/01/09 06:00
PHST- 2014/04/14 00:00 [received]
PHST- 2014/07/29 00:00 [accepted]
PHST- 2015/01/09 06:00 [entrez]
PHST- 2015/01/09 06:00 [pubmed]
PHST- 2015/05/09 06:00 [medline]
AID - S0895-3988(15)60001-0 [pii]
AID - 10.3967/bes2015.001 [doi]
PST - ppublish
SO  - Biomed Environ Sci. 2015 Jan;28(1):1-12. doi: 10.3967/bes2015.001.