PMID- 25567423 OWN - NLM STAT- MEDLINE DCOM- 20160125 LR - 20181113 IS - 1740-634X (Electronic) IS - 0893-133X (Print) IS - 0893-133X (Linking) VI - 40 IP - 7 DP - 2015 Jun TI - Abnormal resting state FMRI activity predicts processing speed deficits in first-episode psychosis. PG - 1631-9 LID - 10.1038/npp.2015.7 [doi] AB - Little is known regarding the neuropsychological significance of resting state functional magnetic resonance imaging (rs-fMRI) activity early in the course of psychosis. Moreover, no studies have used different approaches for analysis of rs-fMRI activity and examined gray matter thickness in the same cohort. In this study, 41 patients experiencing a first-episode of psychosis (including N=17 who were antipsychotic drug-naive at the time of scanning) and 41 individually age- and sex-matched healthy volunteers completed rs-fMRI and structural MRI exams and neuropsychological assessments. We computed correlation matrices for 266 regions-of-interest across the brain to assess global connectivity. In addition, independent component analysis (ICA) was used to assess group differences in the expression of rs-fMRI activity within 20 predefined publicly available templates. Patients demonstrated lower overall rs-fMRI global connectivity compared with healthy volunteers without associated group differences in gray matter thickness assessed within the same regions-of-interest used in this analysis. Similarly, ICA revealed worse rs-fMRI expression scores across all 20 networks in patients compared with healthy volunteers, with posthoc analyses revealing significant (p<0.05; corrected) abnormalities within the caudate nucleus and planum temporale. Worse processing speed correlated significantly with overall lower global connectivity using the region-of-interest approach and lower expression scores within the planum temporale using ICA. Our findings implicate dysfunction in rs-fMRI activity in first-episode psychosis prior to extensive antipsychotic treatment using different analytic approaches (in the absence of concomitant gray matter structural differences) that predict processing speed. FAU - Argyelan, Miklos AU - Argyelan M AD - 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA. FAU - Gallego, Juan A AU - Gallego JA AD - 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA [3] Departments of Psychiatry and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA. FAU - Robinson, Delbert G AU - Robinson DG AD - 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA [3] Departments of Psychiatry and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA. FAU - Ikuta, Toshikazu AU - Ikuta T AD - Department of Communication Sciences and Disorders, School of Applied Sciences, University of Mississippi, University, MS, USA. FAU - Sarpal, Deepak AU - Sarpal D AD - 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA. FAU - John, Majnu AU - John M AD - 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA [3] Department of Mathematics, Hofstra University, Hempstead, NY, USA. FAU - Kingsley, Peter B AU - Kingsley PB AD - Department of Radiology, North Shore University Hospital, Manhasset, NY, USA. FAU - Kane, John AU - Kane J AD - 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA [3] Departments of Psychiatry and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA. FAU - Malhotra, Anil K AU - Malhotra AK AD - 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA [3] Departments of Psychiatry and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA. FAU - Szeszko, Philip R AU - Szeszko PR AD - 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA [3] Departments of Psychiatry and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA. LA - eng GR - R01 MH060004/MH/NIMH NIH HHS/United States GR - M01 RR018535/RR/NCRR NIH HHS/United States GR - R01 MH076995/MH/NIMH NIH HHS/United States GR - P50 MH080173/MH/NIMH NIH HHS/United States GR - P30 MH090590/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20150108 PL - England TA - Neuropsychopharmacology JT - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JID - 8904907 RN - 0 (Antipsychotic Agents) RN - S88TT14065 (Oxygen) SB - IM MH - Adolescent MH - Adult MH - Antipsychotic Agents MH - Cerebral Cortex/*blood supply/*pathology MH - Female MH - Functional Laterality MH - Humans MH - Image Processing, Computer-Assisted MH - Magnetic Resonance Imaging MH - Male MH - Mental Disorders/classification/*complications/drug therapy/*pathology MH - Movement Disorders/diagnosis/*etiology MH - Neuropsychological Tests MH - Oxygen/blood MH - Predictive Value of Tests MH - Principal Component Analysis MH - *Rest MH - Young Adult PMC - PMC4915267 EDAT- 2015/01/09 06:00 MHDA- 2016/01/26 06:00 PMCR- 2016/06/01 CRDT- 2015/01/09 06:00 PHST- 2014/07/25 00:00 [received] PHST- 2014/12/18 00:00 [revised] PHST- 2014/12/19 00:00 [accepted] PHST- 2015/01/09 06:00 [entrez] PHST- 2015/01/09 06:00 [pubmed] PHST- 2016/01/26 06:00 [medline] PHST- 2016/06/01 00:00 [pmc-release] AID - npp20157 [pii] AID - 10.1038/npp.2015.7 [doi] PST - ppublish SO - Neuropsychopharmacology. 2015 Jun;40(7):1631-9. doi: 10.1038/npp.2015.7. Epub 2015 Jan 8.