PMID- 25568287
OWN - NLM
STAT- MEDLINE
DCOM- 20160205
LR  - 20231111
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Print)
IS  - 1461-1457 (Linking)
VI  - 18
IP  - 7
DP  - 2015 Jan 7
TI  - Regional differences in brain-derived neurotrophic factor levels and dendritic 
      spine density confer resilience to inescapable stress.
PG  - pyu121
LID - pyu121 [pii]
LID - 10.1093/ijnp/pyu121 [doi]
AB  - BACKGROUND: In the learned helplessness (LH) paradigm, approximately 35% of rats 
      are resilient to inescapable stress. METHODS: The roles of brain-derived 
      neurotrophic factor (BDNF) and dendritic spine density in the brain regions of LH 
      (susceptible) and non-LH rats (resilient) were examined. Western blot analysis 
      and Golgi staining were performed. RESULTS: BDNF levels in the medial prefrontal 
      cortex, CA3, and dentate gyrus (DG) were significantly lower in the LH group than 
      in the control and non-LH groups, whereas BDNF levels in the nucleus accumbens 
      (NAc) in the LH group but not the non-LH group were significantly higher than 
      those in the control group. Furthermore, spine density in the prelimbic cortex, 
      CA3, and DG was significantly lower in the LH group than in the control and 
      non-LH groups, although spine density in the NAc was significantly higher in the 
      LH group than in the control and non-LH groups. CONCLUSIONS: The results suggest 
      that regional differences in BDNF levels and spine density in rat brain may 
      contribute to resilience to inescapable stress.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of CINP.
FAU - Yang, Chun
AU  - Yang C
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, Japan (Drs Yang, Shirayama, Zhang, Ren, and Hashimoto); Department 
      of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan (Dr 
      Shirayama).
FAU - Shirayama, Yukihiko
AU  - Shirayama Y
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, Japan (Drs Yang, Shirayama, Zhang, Ren, and Hashimoto); Department 
      of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan (Dr 
      Shirayama).
FAU - Zhang, Ji-Chun
AU  - Zhang JC
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, Japan (Drs Yang, Shirayama, Zhang, Ren, and Hashimoto); Department 
      of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan (Dr 
      Shirayama).
FAU - Ren, Qian
AU  - Ren Q
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, Japan (Drs Yang, Shirayama, Zhang, Ren, and Hashimoto); Department 
      of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan (Dr 
      Shirayama).
FAU - Hashimoto, Kenji
AU  - Hashimoto K
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, Japan (Drs Yang, Shirayama, Zhang, Ren, and Hashimoto); Department 
      of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan (Dr 
      Shirayama). hashimoto@faculty.chiba-u.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
DEP - 20150107
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
EIN - Int J Neuropsychopharmacol. 2021 May 18;24(5):446-447. PMID: 33942086
RIN - Int J Neuropsychopharmacol. 2023 Sep 25;26(9):654. PMID: 37669778
MH  - Animals
MH  - Behavior, Animal
MH  - Blotting, Western
MH  - Brain/*metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - CA3 Region, Hippocampal/metabolism
MH  - Dendritic Spines/*pathology
MH  - Dentate Gyrus/metabolism
MH  - *Helplessness, Learned
MH  - Male
MH  - Nucleus Accumbens/metabolism
MH  - Prefrontal Cortex/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Silver Staining/methods
MH  - Stress, Psychological/metabolism/pathology/*psychology
PMC - PMC4540100
OTO - NOTNLM
OT  - BDNF
OT  - depression
OT  - learned helplessness
OT  - resilience
OT  - spine density
EDAT- 2015/01/09 06:00
MHDA- 2016/02/06 06:00
PMCR- 2015/03/04
CRDT- 2015/01/09 06:00
PHST- 2014/11/07 00:00 [received]
PHST- 2014/12/20 00:00 [accepted]
PHST- 2015/01/09 06:00 [entrez]
PHST- 2015/01/09 06:00 [pubmed]
PHST- 2016/02/06 06:00 [medline]
PHST- 2015/03/04 00:00 [pmc-release]
AID - pyu121 [pii]
AID - 10.1093/ijnp/pyu121 [doi]
PST - epublish
SO  - Int J Neuropsychopharmacol. 2015 Jan 7;18(7):pyu121. doi: 10.1093/ijnp/pyu121.