PMID- 25568452
OWN - NLM
STAT- MEDLINE
DCOM- 20150909
LR  - 20181113
IS  - 1477-9145 (Electronic)
IS  - 0022-0949 (Print)
IS  - 0022-0949 (Linking)
VI  - 218
IP  - Pt 1
DP  - 2015 Jan 1
TI  - Epigenetic linkage of aging, cancer and nutrition.
PG  - 59-70
LID - 10.1242/jeb.107110 [doi]
AB  - Epigenetic mechanisms play a pivotal role in the expression of genes and can be 
      influenced by both the quality and quantity of diet. Dietary compounds such as 
      sulforaphane (SFN) found in cruciferous vegetables and epigallocatechin-3-gallate 
      (EGCG) in green tea exhibit the ability to affect various epigenetic mechanisms 
      such as DNA methyltransferase (DNMT) inhibition, histone modifications via 
      histone deacetylase (HDAC), histone acetyltransferase (HAT) inhibition, or 
      noncoding RNA expression. Regulation of these epigenetic mechanisms has been 
      shown to have notable influences on the formation and progression of various 
      neoplasms. We have shown that an epigenetic diet can influence both cellular 
      longevity and carcinogenesis through the modulation of certain key genes that 
      encode telomerase and p16. Caloric restriction (CR) can also play a crucial role 
      in aging and cancer. Reductions in caloric intake have been shown to increase 
      both the life- and health-span in a variety of animal models. Moreover, 
      restriction of glucose has been demonstrated to decrease the incidence of 
      age-related diseases such as cancer and diabetes. A diet rich in compounds such 
      as genistein, SFN and EGCG can positively modulate the epigenome and lead to many 
      health benefits. Also, reducing the quantity of calories and glucose in the diet 
      can confer an increased health-span, including reduced cancer incidence.
CI  - (c) 2015. Published by The Company of Biologists Ltd.
FAU - Daniel, Michael
AU  - Daniel M
AD  - Department of Biology, University of Alabama at Birmingham, 1300 University 
      Boulevard, Birmingham, AL 35294, USA.
FAU - Tollefsbol, Trygve O
AU  - Tollefsbol TO
AD  - Department of Biology, University of Alabama at Birmingham, 1300 University 
      Boulevard, Birmingham, AL 35294, USA Comprehensive Center for Healthy Aging, 
      University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294, 
      USA Comprehensive Cancer Center, University of Alabama at Birmingham, 1802 6th 
      Avenue South, Birmingham, AL 35294, USA Nutrition Obesity Research Center, 
      University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 
      35294, USA Comprehensive Diabetes Center, University of Alabama at Birmingham, 
      1825 University Boulevard, Birmingham, AL 35294, USA trygve@uab.edu.
LA  - eng
GR  - P30 DK079626/DK/NIDDK NIH HHS/United States
GR  - R01 CA178441/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Exp Biol
JT  - The Journal of experimental biology
JID - 0243705
SB  - IM
MH  - Aging/*genetics
MH  - Animals
MH  - Caloric Restriction
MH  - Diet
MH  - *Epigenesis, Genetic
MH  - Humans
MH  - Neoplasms/*genetics
MH  - Nutritional Status/*genetics
PMC - PMC4286704
OTO - NOTNLM
OT  - Aging
OT  - Cancer
OT  - Diet
OT  - Epigenetics
OT  - Nutrition
EDAT- 2015/01/09 06:00
MHDA- 2015/09/10 06:00
PMCR- 2016/01/01
CRDT- 2015/01/09 06:00
PHST- 2015/01/09 06:00 [entrez]
PHST- 2015/01/09 06:00 [pubmed]
PHST- 2015/09/10 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 218/1/59 [pii]
AID - 10.1242/jeb.107110 [doi]
PST - ppublish
SO  - J Exp Biol. 2015 Jan 1;218(Pt 1):59-70. doi: 10.1242/jeb.107110.