PMID- 25568610
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 0975-6299 (Print)
IS  - 0975-6299 (Electronic)
IS  - 0975-6299 (Linking)
VI  - 5
IP  - 4
DP  - 2014 Oct
TI  - EFFECT OF TYPE 2 DIABETES MELLITUS ON BRAIN METABOLITES BY USING PROTON MAGNETIC 
      RESONANCE SPECTROSCOPY-A SYSTEMATIC REVIEW.
PG  - 1118-1123
AB  - Cerebral metabolism will be affected in T2DM either by chronic hyperglycemia or 
      by chronic hypoxia. Proton magnetic resonance spectroscopy ((1)H-MRS) of the 
      brain provides detailed information about the structure, dynamics, reaction state 
      and chemical environment of molecules. It also measures the levels of brain 
      metabolites such as myo-inositol (mI), N acetyl aspartate (NAA), creatine (Cr), 
      choline (Cho), glutamate (Glu), glutamine (Gln) and gamma amino butyric acid 
      (GABA). Several studies suggest that people with type 2 diabetes mellitus (T2DM) 
      are at an increased risk of cognitive impairment in comparison with the general 
      population. The altered metabolites may cause cognitive dysfunction in T2DM. This 
      review article concludes that in T2DM, metabolite levels were altered in 
      different regions of brain.
FAU - Santhakumari, Rajani
AU  - Santhakumari R
AD  - Department of Physiology, MediCiti Institute of Medical Sciences, Hyderabad, 
      Telangana, India.
FAU - Reddy, Indla Yogananda
AU  - Reddy IY
AD  - Department of Physiology, MediCiti Institute of Medical Sciences, Hyderabad, 
      Telangana, India.
FAU - Archana, R
AU  - Archana R
AD  - Department of Physiology, Saveetha Medical College, Chennai, Tamilnadu, India.
LA  - eng
GR  - D43 TW009078/TW/FIC NIH HHS/United States
PT  - Journal Article
PL  - India
TA  - Int J Pharma Bio Sci
JT  - International journal of pharma and bio sciences
JID - 101559697
PMC - PMC4283136
MID - NIHMS637095
OTO - NOTNLM
OT  - Brain metabolites
OT  - Cognition
OT  - Proton Magnetic Resonance Spectroscopy of brain
OT  - Type 2 diabetes mellitus
EDAT- 2015/01/09 06:00
MHDA- 2015/01/09 06:01
PMCR- 2015/01/05
CRDT- 2015/01/09 06:00
PHST- 2015/01/09 06:00 [entrez]
PHST- 2015/01/09 06:00 [pubmed]
PHST- 2015/01/09 06:01 [medline]
PHST- 2015/01/05 00:00 [pmc-release]
PST - ppublish
SO  - Int J Pharma Bio Sci. 2014 Oct;5(4):1118-1123.