PMID- 25568751
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150108
LR  - 20200929
IS  - 2036-3605 (Print)
IS  - 2036-3613 (Electronic)
IS  - 2036-3605 (Linking)
VI  - 6
IP  - 4
DP  - 2014 Oct 27
TI  - Extraskeletal myxoid chondrosarcoma presenting as an intradural spinal mass: 
      report of a rare clinical presentation with an emphasis on differential 
      diagnostic considerations.
PG  - 5586
LID - 10.4081/rt.2014.5586 [doi]
LID - 5586
AB  - Extraskeletal myxoid chondrosarcoma is a rare soft tissue neoplasm that occurs 
      predominantly in the soft tissues of the lower extremities. Herein we present a 
      case of a 29 year old male who presented with bilateral femoral numbness believed 
      to be the result of prior injury to his back. A magnetic resonance imaging 
      revealed a mass in the T4-T5 epidural space compressing the spinal cord. 
      Laminectomy was performed and the lesion removed piecemeal. The pathology 
      specimen consisted of multiple fragments of dura involved by a myxoid neoplasm 
      with a nodular growth pattern. The tumor cells were arranged in anastomosing 
      cords and strands. Individual tumor cells were small, of uniform size and shape, 
      with small hyperchromatic nuclei and scant eosinophilic cytoplasm. 
      Immunohistochemical stains were performed which showed the tumor cells were 
      diffusely positive for vimentin and focally positive for EMA, S-100 protein and 
      cytokeratin, whereas they were negative for CD34 and CD99. Fluorescence in situ 
      hybridization (FISH) studies showed a clonal population of cells with 
      re-arrangement of the EWSR1 locus, confirming the histologic impression of 
      extraskeletal myxoid chondrosarcoma. This is the first report of a case of an 
      extraskeletal myxoid chondrosarcoma arising from the dura, confirmed to have 
      rearrangement of the EWSR1 gene by FISH. There have only been two other cases of 
      dural based extraskeletal myxoid chondrosarcoma reported prior to our case. We 
      also briefly review the published literature and discuss differential diagnostic 
      considerations for this rare tumor.
FAU - Rao, Priya
AU  - Rao P
AD  - Departments of Pathology and Houston, TX, USA.
FAU - Colen, Rivka R
AU  - Colen RR
AD  - Departments of Radiology, University of Texas MD Anderson Cancer Center , 
      Houston, TX, USA.
FAU - Bruner, Janet M
AU  - Bruner JM
AD  - Departments of Pathology and Houston, TX, USA.
FAU - Meis, Jeanne M
AU  - Meis JM
AD  - Departments of Pathology and Houston, TX, USA.
LA  - eng
PT  - Case Reports
DEP - 20141218
PL  - England
TA  - Rare Tumors
JT  - Rare tumors
JID - 101526926
PMC - PMC4274445
OTO - NOTNLM
OT  - FISH
OT  - dura
OT  - extraskeletal myxoid chondrosarcoma
OT  - spine
COIS- Conflict of interests: the authors declare no potential conflict of interests.
EDAT- 2015/01/09 06:00
MHDA- 2015/01/09 06:01
PMCR- 2014/12/18
CRDT- 2015/01/09 06:00
PHST- 2015/08/06 00:00 [received]
PHST- 2014/10/13 00:00 [accepted]
PHST- 2015/01/09 06:00 [entrez]
PHST- 2015/01/09 06:00 [pubmed]
PHST- 2015/01/09 06:01 [medline]
PHST- 2014/12/18 00:00 [pmc-release]
AID - 10.4081/rt.2014.5586 [doi]
PST - epublish
SO  - Rare Tumors. 2014 Dec 18;6(4):5586. doi: 10.4081/rt.2014.5586. eCollection 2014 
      Oct 27.