PMID- 25568756
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150108
LR  - 20200929
IS  - 2036-7430 (Print)
IS  - 2036-7449 (Electronic)
IS  - 2036-7430 (Linking)
VI  - 6
IP  - 4
DP  - 2014 Nov 19
TI  - Extensive Central Nervous System Cryptococcal Disease Presenting as Immune 
      Reconstitution Syndrome in a Patient with Advanced HIV: Report of a Case and 
      Review of Management Dilemmas and Strategies.
PG  - 5576
LID - 10.4081/idr.2014.5576 [doi]
LID - 5576
AB  - One of the complications of the use of antiretroviral therapy (ART), immune 
      reconstitution inflammatory syndrome (IRIS), is particularly problematic in the 
      management of cryptococcal meningitis. We present the case of a 35-year-old male 
      with acquired immune deficiency syndrome diagnosed with extensive central nervous 
      system (CNS) cryptococcal disease, including meningitis and multiple intracranial 
      cysts, diagnosed eight weeks after the initiation of ART. The patient experienced 
      a relapsing and remitting clinical course despite repeated courses of potent 
      antifungal therapy and aggressive management of raised intracranial pressure. 
      This review highlights therapeutic dilemmas and strategies in the management of 
      CNS cryptococcosis complicated with IRIS and highlights gaps in available 
      treatment guidelines.
FAU - Ogbuagu, Onyema
AU  - Ogbuagu O
AD  - Yale HIV/AIDS Program, Section of Infectious Diseases, Yale University School of 
      Medicine , New Haven, CT, USA.
FAU - Villanueva, Merceditas
AU  - Villanueva M
AD  - Yale HIV/AIDS Program, Section of Infectious Diseases, Yale University School of 
      Medicine , New Haven, CT, USA.
LA  - eng
GR  - P30 MH062294/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20141119
PL  - Switzerland
TA  - Infect Dis Rep
JT  - Infectious disease reports
JID - 101537203
PMC - PMC4274402
OTO - NOTNLM
OT  - acquired immune deficiency syndrome
OT  - cryptococcal meningitis
OT  - immune reconstitution inflammatory syndrome
COIS- Conflict of interests: the authors declare no potential conflict of interests.
EDAT- 2015/01/09 06:00
MHDA- 2015/01/09 06:01
PMCR- 2014/11/19
CRDT- 2015/01/09 06:00
PHST- 2014/07/28 00:00 [received]
PHST- 2014/08/13 00:00 [revised]
PHST- 2014/08/14 00:00 [accepted]
PHST- 2015/01/09 06:00 [entrez]
PHST- 2015/01/09 06:00 [pubmed]
PHST- 2015/01/09 06:01 [medline]
PHST- 2014/11/19 00:00 [pmc-release]
AID - 10.4081/idr.2014.5576 [doi]
PST - epublish
SO  - Infect Dis Rep. 2014 Nov 19;6(4):5576. doi: 10.4081/idr.2014.5576. eCollection 
      2014 Nov 19.