PMID- 25569647
OWN - NLM
STAT- MEDLINE
DCOM- 20150413
LR  - 20220330
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 94
IP  - 1
DP  - 2015 Jan
TI  - A new real-time method for detecting the effect of fentanyl using the 
      preoperative pressure pain threshold and Narcotrend index: a randomized study in 
      female surgery patients.
PG  - e316
LID - 10.1097/MD.0000000000000316 [doi]
LID - e316
AB  - Individual variability in the effects of opioid analgesics such as fentanyl 
      remains a major challenge for tailored pharmacological treatment including 
      postoperative analgesia. This study aimed to establish a new real-time method for 
      detecting the effects of fentanyl and their individual differences in the 
      preoperative period, using the pressure pain threshold (PPT) and Narcotrend index 
      (NTI) test.Eighty women undergoing elective surgery under general anesthesia were 
      enrolled in this randomized, double-blinded, placebo-controlled study to receive 
      either intravenous fentanyl (Group F) or saline (Group S). Before (T1) and 5 (T2) 
      and 10 min (T3) after intravenous injection, the PPT, NTI, respiratory rate, 
      heart rate, blood pressure, and pulse oxygen saturation were measured. The 
      initial time at which the Narcotrend index showed a decline was also recorded.In 
      total, 40 patients in Group S and 38 patients in Group F were included in the 
      final analysis. At 5 min and 10 min after intravenous fentanyl administration, 
      the analgesic effect was determined by measuring the PPT, which was significantly 
      increased (P < 0.001), and the sedative effect was detected using the NTI, which 
      was significantly decreased (P < 0.001). The distribution of percentage changes 
      of the PPT and NTI showed individual differences. At T2 and T3, the absolute 
      changes in NTI and PPT were positively correlated (r = 0.444 at T2, P = 0.005; 
      r = 0.332 at T3, P = 0.042).Through the PPT and NTI, it was feasible to easily 
      detect the effects of fentanyl and their individual differences in real time 
      before induction of anesthesia in the operation room. This method could 
      potentially be applied to preoperatively determine patients' sensitivity to 
      fentanyl.
FAU - Duan, Guangyou
AU  - Duan G
AD  - From the Department of Anesthesiology, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Guo, Shanna
AU  - Guo S
FAU - Zhan, Huiming
AU  - Zhan H
FAU - Qi, Dongmei
AU  - Qi D
FAU - Zhang, Yuhao
AU  - Zhang Y
FAU - Zhang, Xianwei
AU  - Zhang X
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Narcotics)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Double-Blind Method
MH  - Female
MH  - Fentanyl/pharmacology/*therapeutic use
MH  - Humans
MH  - Middle Aged
MH  - Narcotics/pharmacology/*therapeutic use
MH  - Pain Measurement/*methods
MH  - Pain Threshold/*drug effects
MH  - Pain, Postoperative/*prevention & control
MH  - Preoperative Period
MH  - Pressure
MH  - Respiratory Rate/drug effects
MH  - Young Adult
PMC - PMC4602846
EDAT- 2015/01/09 06:00
MHDA- 2015/04/14 06:00
PMCR- 2015/01/09
CRDT- 2015/01/09 06:00
PHST- 2015/01/09 06:00 [entrez]
PHST- 2015/01/09 06:00 [pubmed]
PHST- 2015/04/14 06:00 [medline]
PHST- 2015/01/09 00:00 [pmc-release]
AID - 00005792-201501010-00013 [pii]
AID - 10.1097/MD.0000000000000316 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2015 Jan;94(1):e316. doi: 10.1097/MD.0000000000000316.