PMID- 25572192
OWN - NLM
STAT- MEDLINE
DCOM- 20150324
LR  - 20220410
IS  - 1942-5546 (Electronic)
IS  - 0025-6196 (Linking)
VI  - 90
IP  - 1
DP  - 2015 Jan
TI  - The safety of intravenous iron preparations: systematic review and meta-analysis.
PG  - 12-23
LID - S0025-6196(14)00883-0 [pii]
LID - 10.1016/j.mayocp.2014.10.007 [doi]
AB  - OBJECTIVE: To amass all available evidence regarding the safety of intravenous 
      (IV) iron preparations to provide a true balance of efficacy and safety. METHODS: 
      Systematic review and meta-analysis of all randomized clinical trials comparing 
      IV iron to another comparator. All electronic databases until January 1, 2014, 
      were reviewed. Primary outcome was occurrence of severe adverse events (SAEs). 
      Secondary outcomes included all-cause mortality and other adverse events (AEs). 
      Subgroup analysis was performed on the basis of type of IV iron, comparator, 
      treated condition, and system involved. RESULTS: A total of 103 trials published 
      between 1965 through 2013 were included. A total of 10,390 patients were treated 
      with IV iron compared with 4044 patients treated with oral iron, 1329 with no 
      iron, 3335 with placebo, and 155 with intramuscular iron. There was no increased 
      risk of SAEs with IV iron (relative risk [RR], 1.04; 95% CI, 0.93-1.17; I(2)=9%). 
      Subgroup analysis revealed a decreased rate of SAEs when IV iron was used to 
      treat heart failure (RR, 0.45; 95% CI, 0.29-0.70; I(2)=0%). Severe infusion 
      reactions were more common with IV iron (RR, 2.47; 95% CI, 1.43-4.28; I(2)=0%). 
      There was no increased risk of infections with IV iron. Gastrointestinal AEs were 
      reduced with IV iron. CONCLUSION: Intravenous iron therapy is not associated with 
      an increased risk of SAEs or infections. Infusion reactions are more pronounced 
      with IV iron.
CI  - Copyright (c) 2015 Mayo Foundation for Medical Education and Research. Published by 
      Elsevier Inc. All rights reserved.
FAU - Avni, Tomer
AU  - Avni T
AD  - Department of Medicine, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, 
      and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. 
      Electronic address: tomerav@clalit.org.il.
FAU - Bieber, Amir
AU  - Bieber A
AD  - Department of Medicine, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, 
      and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Grossman, Alon
AU  - Grossman A
AD  - Department of Medicine, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, 
      and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Green, Hefziba
AU  - Green H
AD  - Department of Medicine, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, 
      and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Leibovici, Leonard
AU  - Leibovici L
AD  - Department of Medicine, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, 
      and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Gafter-Gvili, Anat
AU  - Gafter-Gvili A
AD  - Department of Medicine, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, 
      and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20141030
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
RN  - E1UOL152H7 (Iron)
SB  - IM
CIN - Mayo Clin Proc. 2015 May;90(5):695-6. PMID: 25939943
CIN - Mayo Clin Proc. 2015 May;90(5):696. PMID: 25939945
CIN - Ann Intern Med. 2015 May 19;162(10):JC8. PMID: 25984881
MH  - *Administration, Intravenous/adverse effects/methods
MH  - Anemia, Iron-Deficiency/*drug therapy
MH  - Drug-Related Side Effects and Adverse Reactions/classification/etiology
MH  - Humans
MH  - *Iron/administration & dosage/adverse effects
MH  - Outcome Assessment, Health Care
MH  - Randomized Controlled Trials as Topic
EDAT- 2015/01/13 06:00
MHDA- 2015/03/25 06:00
CRDT- 2015/01/10 06:00
PHST- 2014/06/18 00:00 [received]
PHST- 2014/08/23 00:00 [revised]
PHST- 2014/10/06 00:00 [accepted]
PHST- 2015/01/10 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/03/25 06:00 [medline]
AID - S0025-6196(14)00883-0 [pii]
AID - 10.1016/j.mayocp.2014.10.007 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 2015 Jan;90(1):12-23. doi: 10.1016/j.mayocp.2014.10.007. Epub 
      2014 Oct 30.