PMID- 25572387
OWN - NLM
STAT- MEDLINE
DCOM- 20150424
LR  - 20220408
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 172
IP  - 4
DP  - 2015 Apr
TI  - Thyroid incidentalomas in patients with multiple endocrine neoplasia type 1.
PG  - 337-42
LID - 10.1530/EJE-14-0897 [doi]
AB  - OBJECTIVE: Currently, little is known about the prevalence of thyroid tumors in 
      multiple endocrine neoplasia type 1 (MEN1) patients and it is unclear whether 
      tumorigenesis of these thyroid tumors is MEN1-related. The aim of the study was 
      to assess the prevalence of thyroid incidentalomas in MEN1 patients compared with 
      nonMEN1 patients and to verify whether thyroid tumorigenesis is MEN1-related. 
      DESIGN: A cross-sectional study. METHODS: The study included two groups: patients 
      with MEN1 and a matched non-MEN1 control group without known thyroid disease, who 
      underwent an ultrasound of the neck for the localization of parathyroid adenoma. 
      Ninety-five MEN1 patients underwent ultrasound of the neck and were matched on 
      gender and age with non-MEN1 patients. The prevalence of thyroid incidentalomas 
      described in the ultrasound report was scored. Multinodular goiters, solitary 
      nodes, and cysts were scored as incidentalomas. Presence of nuclear menin 
      expression was evaluated by menin immunostaining of the thyroid tumors. RESULTS: 
      In the MEN1 group, 43 (45%) patients had a thyroid incidentaloma compared with 48 
      (51%) in the non-MEN1 group, of which 14 (15%) and 16 (17%), respectively, were 
      solitary nodes. Menin was expressed in the nuclei of all evaluated thyroid 
      tumors. CONCLUSIONS: MEN1 patients do not have a higher prevalence of thyroid 
      incidentalomas compared with primary hyperparathyroidism patients without the 
      diagnosis of MEN1. Menin was expressed in the thyroid tumors of MEN1 patients.
CI  - (c) 2015 European Society of Endocrinology.
FAU - Lodewijk, Lutske
AU  - Lodewijk L
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Bongers, Pim J
AU  - Bongers PJ
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Kist, Jakob W
AU  - Kist JW
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Conemans, Elfi B
AU  - Conemans EB
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - de Laat, Joanne M
AU  - de Laat JM
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Pieterman, Carla R C
AU  - Pieterman CR
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - van der Horst-Schrivers, Anouk N A
AU  - van der Horst-Schrivers AN
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Jorna, Ciska
AU  - Jorna C
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Hermus, Ad R
AU  - Hermus AR
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Dekkers, Olaf M
AU  - Dekkers OM
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - de Herder, Wouter W
AU  - de Herder WW
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Drent, Madeleine L
AU  - Drent ML
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Bisschop, Peter H
AU  - Bisschop PH
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Havekes, Bas
AU  - Havekes B
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Rinkes, Inne H M Borel
AU  - Rinkes IH
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Vriens, Menno R
AU  - Vriens MR
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands.
FAU - Valk, Gerlof D
AU  - Valk GD
AD  - Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The 
      NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center 
      Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud 
      University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of 
      Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical 
      Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus 
      Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal 
      MedicineVU University Medical Center, 1007 MB Amsterdam, The 
      NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 
      1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of 
      Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The 
      Netherlands G.D.Valk@umcutrecht.nl.
LA  - eng
PT  - Journal Article
DEP - 20150108
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adenoma/diagnostic imaging/*epidemiology/metabolism
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - *Incidental Findings
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/diagnostic imaging/*epidemiology
MH  - Netherlands/epidemiology
MH  - Prevalence
MH  - Proto-Oncogene Proteins/metabolism
MH  - Thyroid Neoplasms/diagnostic imaging/*epidemiology/metabolism
MH  - Ultrasonography
MH  - Young Adult
EDAT- 2015/01/13 06:00
MHDA- 2015/04/25 06:00
CRDT- 2015/01/10 06:00
PHST- 2015/01/10 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/04/25 06:00 [medline]
AID - EJE-14-0897 [pii]
AID - 10.1530/EJE-14-0897 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2015 Apr;172(4):337-42. doi: 10.1530/EJE-14-0897. Epub 2015 Jan 
      8.