PMID- 25572944
OWN - NLM
STAT- MEDLINE
DCOM- 20150910
LR  - 20151119
IS  - 1421-9832 (Electronic)
IS  - 1018-8665 (Linking)
VI  - 230
IP  - 1
DP  - 2015
TI  - T helper 2 polarization in senile erythroderma with elevated levels of TARC and 
      IgE.
PG  - 62-9
LID - 10.1159/000366502 [doi]
AB  - BACKGROUND: Some cases of senile erythroderma tend to be diagnosed as senile 
      atopic dermatitis (AD) based on elevated levels of immunoglobulin E (IgE) and 
      thymus and activation-regulated chemokine (TARC). However, there are few studies 
      that describe the detailed characteristics of senile erythroderma and senile AD. 
      OBJECTIVE: We examined the association of erythroderma with AD. METHODS: In this 
      retrospective observational study, 68 patients over 65 years of age who presented 
      with erythroderma at Osaka University Hospital were enrolled. Patient data were 
      collected through medical records and descriptive statistics. RESULTS: 47% of the 
      patients were classified as having idiopathic erythroderma and 53% as having 
      secondary erythroderma. In both idiopathic and secondary senile erythroderma 
      patients, serum IgE and TARC levels were elevated. 84% of idiopathic erythroderma 
      patients fulfilled the Japanese Dermatological Associations criteria for AD; 
      however, only 4 patients were finally definitely diagnosed with senile AD. 
      CONCLUSION: Many senile erythroderma patients showed AD-like symptoms due to T 
      helper 2 polarization.
CI  - . (c) 2015 S. Karger AG, Basel.
FAU - Nakano-Tahara, Mayuko
AU  - Nakano-Tahara M
AD  - Department of Dermatology, Osaka University Graduate School of Medicine, Suita, 
      Japan.
FAU - Terao, Mika
AU  - Terao M
FAU - Nishioka, Megumi
AU  - Nishioka M
FAU - Kitaba, Shun
AU  - Kitaba S
FAU - Murota, Hiroyuki
AU  - Murota H
FAU - Katayama, Ichiro
AU  - Katayama I
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150108
PL  - Switzerland
TA  - Dermatology
JT  - Dermatology (Basel, Switzerland)
JID - 9203244
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CCL17 protein, human)
RN  - 0 (Chemokine CCL17)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*blood
MH  - Chemokine CCL17/*blood
MH  - Dermatitis, Atopic/diagnosis/*immunology
MH  - Dermatitis, Exfoliative/blood/diagnosis/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Retrospective Studies
MH  - Th2 Cells/*immunology
EDAT- 2015/01/13 06:00
MHDA- 2015/09/12 06:00
CRDT- 2015/01/10 06:00
PHST- 2014/04/23 00:00 [received]
PHST- 2014/08/07 00:00 [accepted]
PHST- 2015/01/10 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/09/12 06:00 [medline]
AID - 000366502 [pii]
AID - 10.1159/000366502 [doi]
PST - ppublish
SO  - Dermatology. 2015;230(1):62-9. doi: 10.1159/000366502. Epub 2015 Jan 8.