PMID- 25573403
OWN - NLM
STAT- MEDLINE
DCOM- 20151123
LR  - 20240109
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 24
IP  - 2
DP  - 2015 Feb
TI  - Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 
      responses and airway inflammation in mice.
PG  - 383-391
LID - S1567-5769(14)00505-0 [pii]
LID - 10.1016/j.intimp.2014.12.027 [doi]
AB  - Zerumbone is a sesquiterpene compound isolated from the rhizome of wild ginger, 
      Zingiber zerumbet Smith. The rhizomes of the plant are used as a spice and 
      traditional medicine. Zerumbone was shown to possess anticarcinogenic, 
      anti-inflammatory, and antioxidant properties. However, the antiallergic activity 
      and the underlying mechanism of zerumbone have not been reported. Herein, we 
      investigated the immunomodulatory effects of zerumbone on antigen-presenting 
      dendritic cells (DCs) in vitro and its potential therapeutic effects against 
      ovalbumin (OVA)-induced T helper 2 (Th2)-mediated asthma in mice. In the presence 
      of zerumbone, lipopolysaccharide-activated bone marrow-derived DCs enhanced T 
      cell proliferation and Th1 cell polarization in an allogeneic mixed lymphocyte 
      reaction. In animal experiments, mice were sensitized and challenged with OVA, 
      and were orally treated with different doses of zerumbone after sensitization. 
      Circulating titers of OVA-specific antibodies, airway hyperresponsiveness to 
      methacholine, histological changes in lung tissues, the cell composition and 
      cytokine levels in bronchoalveolar lavage fluid, and cytokine profiles of spleen 
      cells were assessed. Compared to OVA-induced hallmarks of asthma, oral 
      administration of zerumbone induced lower OVA-specific immunoglobulin E (IgE) and 
      higher IgG2a antibody production, attenuated airway hyperresponsiveness, 
      prevented eosinophilic pulmonary infiltration, and ameliorated mucus 
      hypersecretion. Zerumbone treatment also reduced the production of eotaxin, 
      keratinocyte-derived chemokine (KC), interleukin (IL)-4, IL-5, IL-10, and IL-13, 
      and promoted Th1 cytokine interferon (IFN)-gamma production in asthmatic mice. Taken 
      together, these results suggest that zerumbone exhibits an antiallergic effect 
      via modulation of Th1/Th2 cytokines in an asthmatic mouse model.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Shieh, Ying-Hua
AU  - Shieh YH
AD  - Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, 
      Taipei, Taiwan.
FAU - Huang, Huei-Mei
AU  - Huang HM
AD  - Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical 
      University, Taipei, Taiwan.
FAU - Wang, Ching-Chiung
AU  - Wang CC
AD  - School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 
      Taiwan.
FAU - Lee, Chen-Chen
AU  - Lee CC
AD  - Department of Microbiology and Immunology, School of Medicine, China Medical 
      University, Taichung, Taiwan.
FAU - Fan, Chia-Kwung
AU  - Fan CK
AD  - Department of Parasitology, College of Medicine, Taipei Medical University, 
      Taipei, Taiwan.
FAU - Lee, Yueh-Lun
AU  - Lee YL
AD  - Department of Microbiology and Immunology, College of Medicine, Taipei Medical 
      University, Taipei, Taiwan. Electronic address: yllee@tmu.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150105
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Sesquiterpenes)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 471-05-6 (zerumbone)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
EIN - Int Immunopharmacol. 2017 Sep;50:371. PMID: 28751107
MH  - Animals
MH  - Anti-Allergic Agents/*pharmacology/therapeutic use
MH  - Asthma/blood/drug therapy/*immunology/pathology
MH  - Bronchial Hyperreactivity/blood/drug therapy/*immunology/pathology
MH  - Bronchoalveolar Lavage Fluid/cytology/immunology
MH  - Cytokines/immunology
MH  - Dendritic Cells/drug effects/immunology
MH  - Female
MH  - Immunoglobulin E/blood/immunology
MH  - Immunoglobulin G/blood
MH  - Lung/drug effects/pathology
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Ovalbumin/immunology
MH  - Sesquiterpenes/*pharmacology/therapeutic use
MH  - Spleen/cytology
MH  - Th1 Cells/*drug effects/immunology
MH  - Th2 Cells/*drug effects/immunology
OTO - NOTNLM
OT  - Asthma
OT  - Dendritic cell
OT  - Th1 cell
OT  - Th2 cell
OT  - Zerumbone
EDAT- 2015/01/13 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/01/10 06:00
PHST- 2014/08/12 00:00 [received]
PHST- 2014/11/21 00:00 [revised]
PHST- 2014/12/22 00:00 [accepted]
PHST- 2015/01/10 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S1567-5769(14)00505-0 [pii]
AID - 10.1016/j.intimp.2014.12.027 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2015 Feb;24(2):383-391. doi: 10.1016/j.intimp.2014.12.027. 
      Epub 2015 Jan 5.