PMID- 25574055
OWN - NLM
STAT- MEDLINE
DCOM- 20150324
LR  - 20220330
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 56
IP  - 2
DP  - 2015 Jan 8
TI  - Correlation between ganglion cell layer thinning and poor visual function after 
      resolution of diabetic macular edema.
PG  - 978-82
LID - 10.1167/iovs.14-15503 [doi]
AB  - PURPOSE: To assess the thickness of the ganglion cell-inner plexiform layer 
      (GCIPL) in eyes with resolved diabetic macular edema (DME), using spectral-domain 
      optical coherence tomography (SD-OCT), and its relationship with the visual 
      function. METHODS: This retrospective observational case-control cohort study 
      included eyes of diabetic patients with resolved DME (r-DME eyes), that is, 
      normal central macular thickness (CMT) after treatment of DME, and eyes of 
      aged-matched diabetic patients without maculopathy (no-DME eyes). The GCIPL 
      thickness was measured on a macular cube SD-OCT scan using a specific automatic 
      segmentation algorithm. Linear regression analyses were performed to determine 
      the association between the GCIPL thickness and the visual acuity (VA) measured 
      at the time of the OCT measurement. RESULTS: Average GCIPL thickness was reduced 
      in r-DME eyes compared with no-DME eyes (74 +/- 14 mum versus 83.2 +/- 6 mum, P = 
      0.0189), whereas no significant difference in mean CMT was observed (260.0 +/- 34 
      mum versus 265.7 +/- 22 mum, P = 0.847). Visual acuity significantly correlated with 
      the average GCIPL thickness (r = 0.8, P < 0.0001) and minimum GCIPL thickness (r 
      = 0.84, P < 0.0001) in r-DME eyes. CONCLUSIONS: Despite favorable anatomic 
      response and restoration of a CMT in the range of normal values after resolution 
      of DME, the GCIPL thickness in r-DME eyes was lower than that in no-DME eyes and 
      correlated with the VA. These results suggest that inner retinal alterations 
      occurring in patients with DME and diabetic retinopathy may lead to visual 
      deficiency persisting after treatment.
CI  - Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.
FAU - Bonnin, Sophie
AU  - Bonnin S
AD  - Service d'Ophtalmologie, Hopital Lariboisiere, AP-HP, Universite Paris 7-Sorbonne 
      Paris Cite, Paris, France.
FAU - Tadayoni, Ramin
AU  - Tadayoni R
AD  - Service d'Ophtalmologie, Hopital Lariboisiere, AP-HP, Universite Paris 7-Sorbonne 
      Paris Cite, Paris, France.
FAU - Erginay, Ali
AU  - Erginay A
AD  - Service d'Ophtalmologie, Hopital Lariboisiere, AP-HP, Universite Paris 7-Sorbonne 
      Paris Cite, Paris, France.
FAU - Massin, Pascale
AU  - Massin P
AD  - Service d'Ophtalmologie, Hopital Lariboisiere, AP-HP, Universite Paris 7-Sorbonne 
      Paris Cite, Paris, France.
FAU - Dupas, Benedicte
AU  - Dupas B
AD  - Service d'Ophtalmologie, Hopital Lariboisiere, AP-HP, Universite Paris 7-Sorbonne 
      Paris Cite, Paris, France.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150108
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Diabetic Retinopathy/complications/*diagnosis/physiopathology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Macular Edema/*diagnosis/etiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
OTO - NOTNLM
OT  - diabetic macular edema
OT  - ganglion cell layer
OT  - optical coherence tomography
EDAT- 2015/01/13 06:00
MHDA- 2015/03/25 06:00
CRDT- 2015/01/10 06:00
PHST- 2015/01/10 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/03/25 06:00 [medline]
AID - iovs.14-15503 [pii]
AID - 10.1167/iovs.14-15503 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2015 Jan 8;56(2):978-82. doi: 10.1167/iovs.14-15503.