PMID- 25574097
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20181113
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 21
IP  - 1
DP  - 2015 Jan 7
TI  - Helicobacter pylori infection in patients with selective immunoglobulin E 
      deficiency.
PG  - 240-5
LID - 10.3748/wjg.v21.i1.240 [doi]
AB  - AIM: To investigate the prevalence and clinical characteristics of Helicobacter 
      pylori (H. pylori)-infected dyspeptic patients with selective immunoglobulin E 
      deficiency (IgEd). METHODS: All individuals who underwent serum total 
      immunoglobulin E (IgE) measurement at the Leumit Healthcare Services (Israel) in 
      2012 were identified in an electronic database search (n = 18487). From these, 
      selected case group subjects were >/= 12 years of age and had serum total IgE < 2 
      kIU/L (n = 158). The control group was selected from a random sampling of the 
      remaining subjects >/= 12 years of age to obtain a case-control ratio of 1:20 (n = 
      3160). Dyspeptic diseases, diagnosed no more than 5 years before serum total IgE 
      testing, were identified and retrieved from the electronic database using 
      specific International Classification of Diseases diagnostic codes. Results of 
      C(13)-urea breath tests were used to identify subjects infected with H. pylori. 
      Categorical variables between case and control subjects were analyzed using 
      Fisher's exact tests, whereas continuous variables were analyzed using chi (2) 
      tests. RESULTS: Dyspepsia was present in 27.2% (43/158) of case subjects and 
      22.7% (718/3160) of controls. Of these, significantly more case subjects (32/43, 
      74.4%) than controls (223/718, 31.1%) were positive for H. pylori (P < 0.01). 
      Esophagogastroduodenoscopy was performed in 19 case and 94 control subjects, 
      revealing that gastritis was more prevalent in IgEd case subjects than in 
      controls (57.9% vs 29.8%, P < 0.05). Furthermore, a significantly greater 
      proportion of case subjects presented with peptic duodenal ulcers (63.2% vs 
      15.9%, P < 0.01). Histopathologic examination showed marked chronic inflammation, 
      lymphoid follicle formation and prominent germinal centers, with 
      polymorphonuclear cell infiltration of gastric glands, that was similar in case 
      and control biopsy tissues. Finally, IgEd case subjects that underwent 
      esophagogastroduodenoscopy were more likely to exhibit treatment-refractory H. 
      pylori infections that require second-line triple antibiotic therapy (47.4% vs 
      11.7%, P < 0.01). CONCLUSION: IgEd is associated with higher rates of H. 
      pylori-associated gastritis and peptic duodenal ulcers.
FAU - Magen, Eli
AU  - Magen E
AD  - Eli Magen, Menachem Schlesinger, Itzhak Ben-Zion, Daniel Vardy, Leumit Health 
      Services, Ashdod 77456, Israel.
FAU - Schlesinger, Menachem
AU  - Schlesinger M
AD  - Eli Magen, Menachem Schlesinger, Itzhak Ben-Zion, Daniel Vardy, Leumit Health 
      Services, Ashdod 77456, Israel.
FAU - Ben-Zion, Itzhak
AU  - Ben-Zion I
AD  - Eli Magen, Menachem Schlesinger, Itzhak Ben-Zion, Daniel Vardy, Leumit Health 
      Services, Ashdod 77456, Israel.
FAU - Vardy, Daniel
AU  - Vardy D
AD  - Eli Magen, Menachem Schlesinger, Itzhak Ben-Zion, Daniel Vardy, Leumit Health 
      Services, Ashdod 77456, Israel.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Breath Tests
MH  - Chi-Square Distribution
MH  - Databases, Factual
MH  - Duodenal Ulcer/diagnosis/epidemiology/immunology/microbiology
MH  - Dyspepsia/diagnosis/epidemiology/immunology/microbiology
MH  - Endoscopy, Gastrointestinal
MH  - Female
MH  - Gastritis/diagnosis/epidemiology/immunology/microbiology
MH  - Helicobacter Infections/diagnosis/*epidemiology/immunology/microbiology
MH  - Helicobacter pylori/immunology/*pathogenicity
MH  - Humans
MH  - Immunoglobulin E/blood/*deficiency
MH  - Immunologic Deficiency Syndromes/diagnosis/*epidemiology/immunology
MH  - Israel/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Serologic Tests
MH  - Young Adult
PMC - PMC4284341
OTO - NOTNLM
OT  - Dyspeptic syndrome
OT  - Helicobacter pylori
OT  - Inflammatory disease
OT  - Peptic ulcer disease
OT  - Selective IgE deficiency
EDAT- 2015/01/13 06:00
MHDA- 2015/09/15 06:00
PMCR- 2015/01/07
CRDT- 2015/01/10 06:00
PHST- 2014/04/20 00:00 [received]
PHST- 2014/06/10 00:00 [revised]
PHST- 2014/07/11 00:00 [accepted]
PHST- 2015/01/10 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
PHST- 2015/01/07 00:00 [pmc-release]
AID - 10.3748/wjg.v21.i1.240 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2015 Jan 7;21(1):240-5. doi: 10.3748/wjg.v21.i1.240.