PMID- 25574593
OWN - NLM
STAT- MEDLINE
DCOM- 20150903
LR  - 20221207
IS  - 1557-8593 (Electronic)
IS  - 1520-9156 (Linking)
VI  - 17
IP  - 1
DP  - 2015 Jan
TI  - Relationship between beta-cell function, metabolic control, and microvascular 
      complications in type 2 diabetes mellitus.
PG  - 29-34
LID - 10.1089/dia.2014.0214 [doi]
AB  - BACKGROUND: This study investigated the relationship among beta-cell function, 
      metabolic control, and diabetic microvascular complications in patients with type 
      2 diabetes mellitus (T2DM). SUBJECTS AND METHODS: In total, 885 patients with 
      type 2 diabetes mellitus (DM) were recruited from January 2012 to January 2014 
      and grouped into three groups according to the area under the curve of C-peptide 
      [AUC(C-pep)] during the 75-g oral glucose tolerance test. Logistic regression 
      analyses were used to evaluate the association between C-peptide and 
      microvascular complications. RESULTS: The prevalence of diabetic microvascular 
      complications decreased from the first to the third AUC(C-pep) tertile (P < 0.01 
      for all), whereas the rates of nonalcoholic fatty liver disease (NAFLD) was 
      positively associated with AUC(C-pep) values. Patients with lower AUC(C-pep) 
      tertile exhibited higher levels of glycosylated hemoglobin and high-density 
      lipoprotein cholesterol and longer duration of DM; however, levels of 
      triglycerides, fasting C-peptide, 2-h C-peptide, body mass index, and homeostasis 
      model assessment of insulin resistance index were lower compared with the third 
      tertile. Comparison among patients with a similar DM duration showed a higher 
      level of AUC(C-pep) was inversely associated with prevalence of microvascular 
      complications. The odds ratios for nephropathy, retinopathy, and neuropathy in 
      the lowest versus the highest AUC(C-pep) tertile were 3.10 (95% confidence 
      interval, 2.01-4.78), 2.83 (1.73-4.64), and 2.04 (1.37-3.04) after adjustment for 
      confounding factors. CONCLUSIONS: Higher AUC(C-pep) levels were associated with a 
      decreased prevalence of microvascular complications and a good level of glycemic 
      control, whereas higher endogenous insulin levels were linked to the components 
      of metabolic syndrome and increased rates of NAFLD.
FAU - Zhao, Lihua
AU  - Zhao L
AD  - Department of Diabetic Neurology, Hospital of Metabolic Disease, Tianjin Medical 
      University , Tianjin, China .
FAU - Ma, Jing
AU  - Ma J
FAU - Wang, Shaoxin
AU  - Wang S
FAU - Xie, Yun
AU  - Xie Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Diabetes Technol Ther
JT  - Diabetes technology & therapeutics
JID - 100889084
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - C-Peptide/*blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Diabetic Angiopathies/epidemiology/*etiology
MH  - Fasting
MH  - Female
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Insulin Resistance
MH  - Insulin-Secreting Cells/*physiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/etiology
MH  - Odds Ratio
MH  - Prevalence
MH  - Triglycerides/blood
EDAT- 2015/01/13 06:00
MHDA- 2015/09/04 06:00
CRDT- 2015/01/10 06:00
PHST- 2015/01/10 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/09/04 06:00 [medline]
AID - 10.1089/dia.2014.0214 [doi]
PST - ppublish
SO  - Diabetes Technol Ther. 2015 Jan;17(1):29-34. doi: 10.1089/dia.2014.0214.