PMID- 25574827
OWN - NLM
STAT- MEDLINE
DCOM- 20150314
LR  - 20221207
IS  - 1537-6605 (Electronic)
IS  - 0002-9297 (Print)
IS  - 0002-9297 (Linking)
VI  - 96
IP  - 1
DP  - 2015 Jan 8
TI  - HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy.
PG  - 136-46
LID - S0002-9297(14)00516-3 [pii]
LID - 10.1016/j.ajhg.2014.12.010 [doi]
AB  - Type 1 narcolepsy, a disorder caused by a lack of hypocretin (orexin), is so 
      strongly associated with human leukocyte antigen (HLA) class II 
      HLA-DQA1( *)01:02-DQB1( *)06:02 (DQ0602) that very few non-DQ0602 cases have been 
      reported. A known triggering factor for narcolepsy is pandemic 2009 influenza 
      H1N1, suggesting autoimmunity triggered by upper-airway infections. Additional 
      effects of other HLA-DQ alleles have been reported consistently across multiple 
      ethnic groups. Using over 3,000 case and 10,000 control individuals of European 
      and Chinese background, we examined the effects of other HLA loci. After careful 
      matching of HLA-DR and HLA-DQ in case and control individuals, we found strong 
      protective effects of HLA-DPA1( *)01:03-DPB1( *)04:02 (DP0402; odds ratio [OR] = 
      0.51 [0.38-0.67], p = 1.01 x 10(-6)) and HLA-DPA1( *)01:03-DPB1( *)04:01 (DP0401; 
      OR = 0.61 [0.47-0.80], p = 2.07 x 10(-4)) and predisposing effects of 
      HLA-DPB1( *)05:01 in Asians (OR = 1.76 [1.34-2.31], p = 4.71 x 10(-05)). Similar 
      effects were found by conditional analysis controlling for HLA-DR and HLA-DQ with 
      DP0402 (OR = 0.45 [0.38-0.55] p = 8.99 x 10(-17)) and DP0501 (OR = 1.38 
      [1.18-1.61], p = 7.11 x 10(-5)). HLA-class-II-independent associations with 
      HLA-A( *)11:01 (OR = 1.32 [1.13-1.54], p = 4.92 x 10(-4)), HLA-B( *)35:03 (OR = 
      1.96 [1.41-2.70], p = 5.14 x 10(-5)), and HLA-B( *)51:01 (OR = 1.49 [1.25-1.78], p 
      = 1.09 x 10(-5)) were also seen across ethnic groups in the HLA class I region. 
      These effects might reflect modulation of autoimmunity or indirect effects of HLA 
      class I and HLA-DP alleles on response to viral infections such as that of 
      influenza.
CI  - Copyright (c) 2015 The American Society of Human Genetics. Published by Elsevier 
      Inc. All rights reserved.
FAU - Ollila, Hanna M
AU  - Ollila HM
AD  - Stanford University Center for Sleep Sciences, Palo Alto, CA 94304, USA.
FAU - Ravel, Jean-Marie
AU  - Ravel JM
AD  - Stanford University Center for Sleep Sciences, Palo Alto, CA 94304, USA.
FAU - Han, Fang
AU  - Han F
AD  - Department of Pulmonary Medicine, Peking University People's Hospital, 100044 
      Beijing, China.
FAU - Faraco, Juliette
AU  - Faraco J
AD  - Stanford University Center for Sleep Sciences, Palo Alto, CA 94304, USA.
FAU - Lin, Ling
AU  - Lin L
AD  - Stanford University Center for Sleep Sciences, Palo Alto, CA 94304, USA.
FAU - Zheng, Xiuwen
AU  - Zheng X
AD  - Department of Biostatistics, University of Washington, PO box 357232, Seattle, WA 
      98195, USA.
FAU - Plazzi, Giuseppe
AU  - Plazzi G
AD  - Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Ugo 
      Foscolo 7, 40123 Bologna, Italy; IRCCS Institute of Neurological Sciences, 40139 
      Bologna, Italy.
FAU - Dauvilliers, Yves
AU  - Dauvilliers Y
AD  - INSERM U1061, Reference Center for Narcolepsy, Sleep-Wake Disorders Center, 
      Department of Neurology, Gui-de-Chauliac Hospital, Centre Hospitalier Regional 
      Universitaire Montpellier, 34090 Montpellier, France.
FAU - Pizza, Fabio
AU  - Pizza F
AD  - Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Ugo 
      Foscolo 7, 40123 Bologna, Italy; IRCCS Institute of Neurological Sciences, 40139 
      Bologna, Italy.
FAU - Hong, Seung-Chul
AU  - Hong SC
AD  - Department of Psychiatry, St. Vincent's Hospital, The Catholic University of 
      Korea, 442-723 Suwon, Korea.
FAU - Jennum, Poul
AU  - Jennum P
AD  - Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, 
      University of Copenhagen, Glostrup Hospital, 2600 Glostrup, Denmark.
FAU - Knudsen, Stine
AU  - Knudsen S
AD  - Norwegian Resource Center for ADHD, TS, and Narcolepsy, Oslo University Hospital, 
      0450 Ulleval, Norway.
FAU - Kornum, Birgitte R
AU  - Kornum BR
AD  - Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, 
      University of Copenhagen, Glostrup Hospital, 2600 Glostrup, Denmark; Molecular 
      Sleep Laboratory, Department of Diagnostics, Glostrup Hospital, 2600 Glostrup, 
      Denmark.
FAU - Dong, Xiao Song
AU  - Dong XS
AD  - Department of Pulmonary Medicine, Peking University People's Hospital, 100044 
      Beijing, China.
FAU - Yan, Han
AU  - Yan H
AD  - Department of Pulmonary Medicine, Peking University People's Hospital, 100044 
      Beijing, China.
FAU - Hong, Heeseung
AU  - Hong H
AD  - Stanford University Center for Sleep Sciences, Palo Alto, CA 94304, USA.
FAU - Coquillard, Cristin
AU  - Coquillard C
AD  - Department of Pathology, Stanford University School of Medicine, Stanford, CA 
      94304, USA.
FAU - Mahlios, Joshua
AU  - Mahlios J
AD  - Stanford University Center for Sleep Sciences, Palo Alto, CA 94304, USA.
FAU - Jolanki, Otto
AU  - Jolanki O
AD  - Stanford University Center for Sleep Sciences, Palo Alto, CA 94304, USA.
FAU - Einen, Mali
AU  - Einen M
AD  - Stanford University Center for Sleep Sciences, Palo Alto, CA 94304, USA.
FAU - Arnulf, Isabelle
AU  - Arnulf I
FAU - Hogl, Birgit
AU  - Hogl B
AD  - Department of Neurology, Medical University of Innsbruck, 6020 Innsbruck, 
      Austria.
FAU - Frauscher, Birgit
AU  - Frauscher B
AD  - Department of Neurology, Medical University of Innsbruck, 6020 Innsbruck, 
      Austria.
FAU - Crowe, Catherine
AU  - Crowe C
AD  - Mater Private Hospital, Dublin 7, Ireland.
FAU - Partinen, Markku
AU  - Partinen M
AD  - Helsinki Sleep Clinic, Vitalmed Research Centre, 00420 Helsinki, Finland; 
      Department of Clinical Neurosciences, University of Helsinki, 00100 Helsinki, 
      Finland.
FAU - Huang, Yu Shu
AU  - Huang YS
AD  - Chang Gung Memorial Hospital and University, Taipei 10591, Taiwan.
FAU - Bourgin, Patrice
AU  - Bourgin P
AD  - Department of Sleep Medicine, Strasbourg University Hospital, Strasbourg 
      University, 67084 Strasbourg, France.
FAU - Vaarala, Outi
AU  - Vaarala O
AD  - Institute of Clinical Medicine, University of Helsinki, 00100 Helsinki, Finland.
FAU - Desautels, Alex
AU  - Desautels A
AD  - Center for Advanced Research in Sleep Medicine, Hopital du Sacre-Coeur and 
      Department of Neurosciences, University of Montreal, Montreal, QC H3T 1J4, 
      Canada.
FAU - Montplaisir, Jacques
AU  - Montplaisir J
AD  - Center for Advanced Research in Sleep Medicine, Hopital du Sacre-Coeur and 
      Department of Psychiatry, University of Montreal, Montreal QC H3T 1J4, Canada.
FAU - Mack, Steven J
AU  - Mack SJ
AD  - Children's Hospital Oakland Research Institute, 5700 Martin Luther King Junior 
      Way, Oakland, CA 94609-1673, USA.
FAU - Mindrinos, Michael
AU  - Mindrinos M
AD  - Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA.
FAU - Fernandez-Vina, Marcelo
AU  - Fernandez-Vina M
AD  - Department of Pathology, Stanford University School of Medicine, Stanford, CA 
      94304, USA.
FAU - Mignot, Emmanuel
AU  - Mignot E
AD  - Stanford University Center for Sleep Sciences, Palo Alto, CA 94304, USA. 
      Electronic address: mignot@stanford.edu.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - P50 NS023724/NS/NINDS NIH HHS/United States
GR  - NS23724/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - Narcolepsy 1
SB  - IM
EIN - Am J Hum Genet. 2015 May 7;96(5):852. Lavault, Sophie [removed]; Arnulf, Isabelle 
      [added]
MH  - Alleles
MH  - Asian People
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - Genetic Loci
MH  - HLA-B Antigens/genetics/metabolism
MH  - HLA-DP Antigens/genetics/metabolism
MH  - HLA-DP beta-Chains/*genetics/metabolism
MH  - HLA-DQ alpha-Chains/genetics/metabolism
MH  - HLA-DR Antigens/genetics/metabolism
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics/metabolism
MH  - Humans
MH  - Influenza A Virus, H1N1 Subtype/genetics
MH  - Male
MH  - Narcolepsy/*genetics
MH  - Risk Factors
MH  - White People
PMC - PMC4289679
EDAT- 2015/01/13 06:00
MHDA- 2015/03/15 06:00
PMCR- 2015/07/08
CRDT- 2015/01/10 06:00
PHST- 2014/09/23 00:00 [received]
PHST- 2014/12/08 00:00 [accepted]
PHST- 2015/01/10 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/03/15 06:00 [medline]
PHST- 2015/07/08 00:00 [pmc-release]
AID - S0002-9297(14)00516-3 [pii]
AID - 10.1016/j.ajhg.2014.12.010 [doi]
PST - ppublish
SO  - Am J Hum Genet. 2015 Jan 8;96(1):136-46. doi: 10.1016/j.ajhg.2014.12.010.