PMID- 25575479
OWN - NLM
STAT- MEDLINE
DCOM- 20150918
LR  - 20181113
IS  - 1995-8218 (Electronic)
IS  - 1673-7067 (Print)
IS  - 1995-8218 (Linking)
VI  - 31
IP  - 1
DP  - 2015 Feb
TI  - New hypothesis and treatment targets of depression: an integrated view of key 
      findings.
PG  - 61-74
LID - 10.1007/s12264-014-1486-4 [doi]
AB  - Major depressive disorder (MDD) is a common and devastating psychiatric disorder 
      characterized by persistent low mood, cognitive disorder, and impaired social 
      function. Despite its complex mechanisms, increasing evidence has identified the 
      involvement of neurotrophic factors, inflammatory cytokines, the 
      hypothalamus-pituitary-adrenal axis, and glutamate receptors in the 
      pathophysiology of this illness. The present review synthesizes recent research 
      achievements to define the network between different hypotheses of MDD and to 
      understand which part is most pivotal for its pathogenesis. By integrating 
      MDD-related signal pathways, we highlight brain-derived neurotrophic factor 
      (BDNF) dysfunction and increased apoptosis as the final common cascades, and new 
      therapeutic strategies aiming to enhance BDNF function have been shown to exert a 
      rapid and effective antidepressant action.
FAU - Cai, Shangli
AU  - Cai S
AD  - Mental Health Institute and Key Laboratory of Psychiatry of Hunan Province, The 
      Second Xiangya Hospital, Central South University, Changsha, 410011, China.
FAU - Huang, Shucai
AU  - Huang S
FAU - Hao, Wei
AU  - Hao W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150109
PL  - Singapore
TA  - Neurosci Bull
JT  - Neuroscience bulletin
JID - 101256850
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Glutamate)
SB  - IM
MH  - Antidepressive Agents/therapeutic use
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Circadian Rhythm
MH  - Cytokines/metabolism
MH  - Depressive Disorder, Major/*drug therapy/etiology/*metabolism/*physiopathology
MH  - Humans
MH  - Hypothalamus/metabolism
MH  - Inflammation/metabolism
MH  - Nerve Growth Factors/metabolism
MH  - Pituitary-Adrenal System/metabolism
MH  - Receptors, Glutamate/metabolism
MH  - Signal Transduction
PMC - PMC5562637
EDAT- 2015/01/13 06:00
MHDA- 2015/09/19 06:00
PMCR- 2016/02/01
CRDT- 2015/01/11 06:00
PHST- 2014/07/10 00:00 [received]
PHST- 2014/10/05 00:00 [accepted]
PHST- 2015/01/11 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/09/19 06:00 [medline]
PHST- 2016/02/01 00:00 [pmc-release]
AID - 1486 [pii]
AID - 10.1007/s12264-014-1486-4 [doi]
PST - ppublish
SO  - Neurosci Bull. 2015 Feb;31(1):61-74. doi: 10.1007/s12264-014-1486-4. Epub 2015 
      Jan 9.