PMID- 25576682
OWN - NLM
STAT- MEDLINE
DCOM- 20160107
LR  - 20150413
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 21
IP  - 4
DP  - 2015 Apr
TI  - Differential prognostic impact of resting heart rate in older compared with 
      younger patients with chronic heart failure--insights from TIME-CHF.
PG  - 347-54
LID - S1071-9164(14)01367-0 [pii]
LID - 10.1016/j.cardfail.2014.12.014 [doi]
AB  - BACKGROUND: There is little information regarding the prognostic role of resting 
      heart rate (HR) in older compared with younger patients with chronic heart 
      failure (HF). METHODS AND RESULTS: In patients enrolled in the Trial of 
      Intensified Medical Therapy in Elderly Patients With Congestive Heart Failure 
      (TIME-CHF) with sinus rhythm, effects of baseline HR (>/=70 vs <70 beats/min [bpm]) 
      on 18-month outcomes were compared between older (>/=75 years; n = 186) and younger 
      (<75 years; n = 141) patients. Older patients with lower (61 +/- 6 bpm) and higher 
      (83 +/- 9 bpm) HR had similar left ventricular ejection fraction (LVEF), New York 
      Heart Association (NYHA) functional class, N-terminal pro-B-type natriuretic 
      peptide (NT-proBNP), and survival and HF hospitalization-free survival. In 
      contrast, younger patients with higher HR (81 +/- 7 bpm) had higher NT-proBNP and 
      NYHA functional class, lower LVEF, and a higher risk of death (hazard ratio 4.01 
      [95% confidence interval (CI) 1.17 -13.69]; P = .02) and death or HF 
      hospitalization (hazard ratio 2.35 [95% CI 1.01-5.50]; P = .04) than those with 
      lower HR (62 +/- 5 bpm), with the association between higher HR and survival 
      remaining significant after adjustment for NYHA functional class, LVEF, and 
      NT-proBNP. CONCLUSIONS: In contrast to HF patients aged <75 years, we found no 
      association between HR and worse outcomes in HF patients aged >/=75 years.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Zurek, Marzena
AU  - Zurek M
AD  - Department of Cardiology, Kantonsspital, St Gallen, Switzerland.
FAU - Maeder, Micha T
AU  - Maeder MT
AD  - Department of Cardiology, Kantonsspital, St Gallen, Switzerland; Department of 
      Cardiology, University Hospital, Basel, Switzerland. Electronic address: 
      micha.maeder@kssg.ch.
FAU - Rickli, Hans
AU  - Rickli H
AD  - Department of Cardiology, Kantonsspital, St Gallen, Switzerland.
FAU - Muzzarelli, Stefano
AU  - Muzzarelli S
AD  - Department of Cardiology, University Hospital, Basel, Switzerland; Cardiocentro, 
      Lugano, Switzerland.
FAU - Sanders-van Wijk, Sandra
AU  - Sanders-van Wijk S
AD  - Cardiovascular Research Institute Maastricht, Maastricht University Medical 
      Center, Maastricht, The Netherlands.
FAU - Abbuhl, Heidi
AU  - Abbuhl H
AD  - Department of Cardiology, University Hospital, Basel, Switzerland; Department of 
      Cardiology, Kantonsspital, Frauenfeld, Switzerland.
FAU - Handschin, Rolf
AU  - Handschin R
AD  - Department of Cardiology, Kantonsspital, Baselland Bruderholz, Switzerland.
FAU - Jeker, Urs
AU  - Jeker U
AD  - Department of Cardiology, Kantonsspital, Luzern, Switzerland.
FAU - Pfisterer, Matthias
AU  - Pfisterer M
AD  - Department of Cardiology, University Hospital, Basel, Switzerland.
FAU - Brunner-la Rocca, Hans-Peter
AU  - Brunner-la Rocca HP
AD  - Department of Cardiology, University Hospital, Basel, Switzerland; Cardiovascular 
      Research Institute Maastricht, Maastricht University Medical Center, Maastricht, 
      The Netherlands.
CN  - TIME-CHF Investigators
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150107
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Heart Failure/*physiopathology
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Rest/*physiology
MH  - Stroke Volume/physiology
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - Heart rate
OT  - TIME-CHF
OT  - age
OT  - chronic heart failure
OT  - prognosis
EDAT- 2015/01/13 06:00
MHDA- 2016/01/08 06:00
CRDT- 2015/01/11 06:00
PHST- 2014/09/14 00:00 [received]
PHST- 2014/12/13 00:00 [revised]
PHST- 2014/12/29 00:00 [accepted]
PHST- 2015/01/11 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2016/01/08 06:00 [medline]
AID - S1071-9164(14)01367-0 [pii]
AID - 10.1016/j.cardfail.2014.12.014 [doi]
PST - ppublish
SO  - J Card Fail. 2015 Apr;21(4):347-54. doi: 10.1016/j.cardfail.2014.12.014. Epub 
      2015 Jan 7.