PMID- 25576963
OWN - NLM
STAT- MEDLINE
DCOM- 20150921
LR  - 20150209
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 282
DP  - 2015 Apr 1
TI  - Alterations in brain neurotrophic and glial factors following early age chronic 
      methylphenidate and cocaine administration.
PG  - 125-32
LID - S0166-4328(15)00003-0 [pii]
LID - 10.1016/j.bbr.2014.12.058 [doi]
AB  - Attention deficit hyperactivity disorder (ADHD) overdiagnosis and a 
      pharmacological attempt to increase cognitive performance, are the major causes 
      for the frequent (ab)use of psychostimulants in non-ADHD individuals. 
      Methylphenidate is a non-addictive psychostimulant, although its mode of action 
      resembles that of cocaine, a well-known addictive and abused drug. Neuronal- and 
      glial-derived growth factors play a major role in the development, maintenance 
      and survival of neurons in the central nervous system. We hypothesized that 
      methylphenidate and cocaine treatment affect the expression of such growth 
      factors. Beginning on postnatal day (PND) 14, male Sprague Dawley rats were 
      treated chronically with either cocaine or methylphenidate. The rats were 
      examined behaviorally and biochemically at several time points (PND 35, 56, 70 
      and 90). On PND 56, rats treated with cocaine or methylphenidate from PND 14 
      through PND 35 exhibited increased hippocampal glial-cell derived neurotrophic 
      factor (GDNF) mRNA levels, after 21 withdrawal days, compared to the 
      saline-treated rats. We found a significant association between cocaine and 
      methylphenidate treatments and age progression in the prefrontal protein 
      expression of brain derived neurotrophic factor (BDNF). Neither treatments 
      affected the behavioral parameters, although acute cocaine administration was 
      associated with increased locomotor activity. It is possible that the increased 
      hippocampal GDNF mRNA levels, may be relevant to the reduced rate of drug seeking 
      behavior in ADHD adolescence that were maintained from childhood on 
      methylphenidate. BDNF protein level increase with age, as well as following 
      stimulant treatments at early age may be relevant to the neurobiology and 
      pharmacotherapy of ADHD.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Simchon-Tenenbaum, Yaarit
AU  - Simchon-Tenenbaum Y
AD  - Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv 
      University, Israel.
FAU - Weizman, Abraham
AU  - Weizman A
AD  - Research Unit, Geha Mental Health Center, Petah-Tikva, Israel; Felsenstein 
      Medical Research Center, Petah-Tikva, Israel.
FAU - Rehavi, Moshe
AU  - Rehavi M
AD  - Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv 
      University, Israel; The Dr. Miriam and Sheldon G. Adelson Chair, Center for the 
      Biology of Addictive Diseases, Israel. Electronic address: 
      mrehavi@post.tau.ac.il.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150108
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Cocaine/*pharmacology
MH  - Glial Cell Line-Derived Neurotrophic Factor/*metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Locomotion/drug effects
MH  - Male
MH  - Methylphenidate/*pharmacology
MH  - Motor Activity/drug effects
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - RNA, Messenger/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
OTO - NOTNLM
OT  - Attention deficit hyperactivity disorder (ADHD)
OT  - Brain derived neurotrophic factor (BDNF)
OT  - Cocaine
OT  - Glial-cell derived neurotrophic factor (GDNF)
OT  - Methylphenidate (MPH)
EDAT- 2015/01/13 06:00
MHDA- 2015/09/22 06:00
CRDT- 2015/01/11 06:00
PHST- 2014/10/20 00:00 [received]
PHST- 2014/12/30 00:00 [revised]
PHST- 2014/12/31 00:00 [accepted]
PHST- 2015/01/11 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/09/22 06:00 [medline]
AID - S0166-4328(15)00003-0 [pii]
AID - 10.1016/j.bbr.2014.12.058 [doi]
PST - ppublish
SO  - Behav Brain Res. 2015 Apr 1;282:125-32. doi: 10.1016/j.bbr.2014.12.058. Epub 2015 
      Jan 8.