PMID- 25577068
OWN - NLM
STAT- MEDLINE
DCOM- 20150820
LR  - 20220317
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 175
DP  - 2015 May 15
TI  - Optimization of a phase separation based magnetic-stirring salt-induced 
      liquid-liquid microextraction method for determination of fluoroquinolones in 
      food.
PG  - 181-8
LID - S0308-8146(14)01870-6 [pii]
LID - 10.1016/j.foodchem.2014.11.132 [doi]
AB  - Herein, we developed a novel integrated apparatus to perform phase separation 
      based on magnetic-stirring, salt-induced, liquid-liquid microextraction for 
      determination of five fluoroquinolones in animal-based foods by HPLC analysis. 
      The novel integrated apparatus consisted of three simple HDPE (high density 
      polyethylene) parts that were used to separate the solvent from the aqueous 
      solution prior to retrieving the extractant. The extraction parameters were 
      optimized using the response surface method based on central composite design: 
      791 muL of acetone solvent, 2.5 g of Na2SO4, pH 1.7, 3.0 min of stir time, and 5.5 
      min centrifugation. The limits of detection were 0.07-0.53 mug kg(-1) and 
      recoveries were 91.6-105.0% for the five fluoroquinolones from milk, eggs and 
      honey. This method is easily constructed from inexpensive materials, extraction 
      efficiency is high, and the approach is compatible with HPLC analysis. Thus, it 
      has excellent prospects for sample pre-treatment and analysis of fluoroquinolones 
      in animal-based foods.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Gao, Ming
AU  - Gao M
AD  - College of Environmental Sciences and Public Health, Wenzhou Medical University, 
      Wenzhou 325035, China.
FAU - Wang, Huili
AU  - Wang H
AD  - College of Environmental Sciences and Public Health, Wenzhou Medical University, 
      Wenzhou 325035, China. Electronic address: whuili@163.com.
FAU - Ma, Meiping
AU  - Ma M
AD  - College of Environmental Sciences and Public Health, Wenzhou Medical University, 
      Wenzhou 325035, China.
FAU - Zhang, Yuna
AU  - Zhang Y
AD  - College of Environmental Sciences and Public Health, Wenzhou Medical University, 
      Wenzhou 325035, China.
FAU - Yin, Xiaohan
AU  - Yin X
AD  - College of Environmental Sciences and Public Health, Wenzhou Medical University, 
      Wenzhou 325035, China.
FAU - Dahlgren, Randy A
AU  - Dahlgren RA
AD  - Department of Land, Air and Water Resources, University of California, Davis, CA 
      95616, USA.
FAU - Du, Dongli
AU  - Du D
AD  - College of Environmental Sciences and Public Health, Wenzhou Medical University, 
      Wenzhou 325035, China.
FAU - Wang, Xuedong
AU  - Wang X
AD  - College of Environmental Sciences and Public Health, Wenzhou Medical University, 
      Wenzhou 325035, China. Electronic address: wxdong@wzmc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141129
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 0 (Fluoroquinolones)
RN  - 0 (Solutions)
RN  - 0 (Solvents)
RN  - 0 (Sulfates)
RN  - 0YPR65R21J (sodium sulfate)
RN  - 1364PS73AF (Acetone)
SB  - IM
MH  - Acetone/isolation & purification
MH  - Animals
MH  - Chromatography, High Pressure Liquid/methods
MH  - Eggs/analysis
MH  - Fluoroquinolones/*analysis
MH  - Food Analysis/*methods
MH  - Honey/analysis
MH  - Liquid Phase Microextraction/*methods
MH  - Magnetic Phenomena
MH  - Milk/chemistry
MH  - Solutions/chemistry
MH  - Solvents/isolation & purification
MH  - Sulfates
OTO - NOTNLM
OT  - Animal-based food
OT  - Central composite design
OT  - Combining apparatus
OT  - Fluoroquinolones
OT  - Magnetic-stirring salt-induced liquid-liquid microextraction
OT  - Phase separation prior to collection
EDAT- 2015/01/13 06:00
MHDA- 2015/08/21 06:00
CRDT- 2015/01/12 06:00
PHST- 2014/03/21 00:00 [received]
PHST- 2014/07/27 00:00 [revised]
PHST- 2014/11/23 00:00 [accepted]
PHST- 2015/01/12 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/08/21 06:00 [medline]
AID - S0308-8146(14)01870-6 [pii]
AID - 10.1016/j.foodchem.2014.11.132 [doi]
PST - ppublish
SO  - Food Chem. 2015 May 15;175:181-8. doi: 10.1016/j.foodchem.2014.11.132. Epub 2014 
      Nov 29.