PMID- 25577131
OWN - NLM
STAT- MEDLINE
DCOM- 20160719
LR  - 20181113
IS  - 1433-8726 (Electronic)
IS  - 0724-4983 (Linking)
VI  - 33
IP  - 10
DP  - 2015 Oct
TI  - Fifteen-year single-centre experience with three different surgical procedures of 
      nerve-sparing cystectomy in selected organ-confined bladder cancer patients.
PG  - 1389-95
LID - 10.1007/s00345-015-1482-y [doi]
AB  - OBJECTIVES: To evaluate technical feasibility and oncologic and functional 
      outcomes of three different surgical procedures of nerve-sparing radical 
      cystectomy (NS-RC) for the treatment of organ-confined bladder cancer at a single 
      referral centre. MATERIALS AND METHODS: All consecutive cases of NS-RC carried 
      out between 1997 and 2012 were retrospectively analysed. NS-RC included 
      nerve-sparing cysto-vesicleprostatectomy (NS-CVP), capsule-sparing cystectomy 
      (CS-C) and seminal-sparing cysto-prostatectomy (SS-CP). Peri-operative parameters 
      and post-operative outcomes were analysed. RESULTS: Overall, 90 patients 
      underwent NS-RC, 35 (38.9 %) of whom received a NS-CVP, while 36 (40 %) and 19 
      (21.1 %) underwent capsule CS-C and SS-CP, respectively. No difference was 
      registered comparing oncologic outcomes of the three different techniques; 
      however, two local recurrences after CS-C were attributed to the surgical 
      technique. Complete post-operative daytime and night-time urinary continence (UC) 
      at 24 and 48 months was achieved in 94.4 and 74.4 % and in 88.8 and 84.4 % of 
      cases, respectively. CS-C showed both the best UC and sexual function 
      preservation rate at early follow-up (24 months). Overall, a satisfactory 
      post-operative erectile function (IIEF-5 >/= 22) was proved in 57 (68.6 %) and 54 
      (65.0 %) patients at 24 and 48 months, respectively. Significant difference was 
      found when comparing sexual function preservation rate of NS-CVP (28.5 %) to that 
      of CS-C (91.6 %) and SS-CP (84.2 %). CONCLUSION: NS-RC for male patients 
      accounted for 7.4 % of overall radical cystectomy. To a limited extent of the 
      selected organ-confined bladder cancers treated, the three different procedures 
      analysed showed comparable results in terms of local recurrence and 
      cancer-specific survival. Both CS-C and SS-CP procedures provided excellent 
      functional outcomes when compared to original NS-CVP.
FAU - Colombo, R
AU  - Colombo R
AD  - Departments of Urology, Urological Research Institute, Vita-Salute San Raffaele 
      University, San Raffaele Hospital, San Raffaele Scientific Institute, Via 
      Olgettina, 60-20132, Milan, Italy.
FAU - Pellucchi, F
AU  - Pellucchi F
AD  - Department of Urology, Papa Giovanni XXIII Hospital, Bergamo, Italy.
FAU - Moschini, M
AU  - Moschini M
AD  - Departments of Urology, Urological Research Institute, Vita-Salute San Raffaele 
      University, San Raffaele Hospital, San Raffaele Scientific Institute, Via 
      Olgettina, 60-20132, Milan, Italy. marco.moschini87@gmail.com.
FAU - Gallina, A
AU  - Gallina A
AD  - Departments of Urology, Urological Research Institute, Vita-Salute San Raffaele 
      University, San Raffaele Hospital, San Raffaele Scientific Institute, Via 
      Olgettina, 60-20132, Milan, Italy.
FAU - Bertini, R
AU  - Bertini R
AD  - Departments of Urology, Urological Research Institute, Vita-Salute San Raffaele 
      University, San Raffaele Hospital, San Raffaele Scientific Institute, Via 
      Olgettina, 60-20132, Milan, Italy.
FAU - Salonia, A
AU  - Salonia A
AD  - Departments of Urology, Urological Research Institute, Vita-Salute San Raffaele 
      University, San Raffaele Hospital, San Raffaele Scientific Institute, Via 
      Olgettina, 60-20132, Milan, Italy.
FAU - Rigatti, P
AU  - Rigatti P
AD  - Departments of Urology, Urological Research Institute, Vita-Salute San Raffaele 
      University, San Raffaele Hospital, San Raffaele Scientific Institute, Via 
      Olgettina, 60-20132, Milan, Italy.
FAU - Montorsi, F
AU  - Montorsi F
AD  - Departments of Urology, Urological Research Institute, Vita-Salute San Raffaele 
      University, San Raffaele Hospital, San Raffaele Scientific Institute, Via 
      Olgettina, 60-20132, Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150111
PL  - Germany
TA  - World J Urol
JT  - World journal of urology
JID - 8307716
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cystectomy/*methods
MH  - Follow-Up Studies
MH  - *Forecasting
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Penile Erection/*physiology
MH  - Postoperative Period
MH  - Prostatectomy/methods
MH  - Prostatic Neoplasms/physiopathology/surgery
MH  - Retrospective Studies
MH  - Sexuality/*physiology
MH  - Treatment Outcome
MH  - Urinary Bladder Neoplasms/physiopathology/*surgery
OTO - NOTNLM
OT  - Cancer-specific survival
OT  - Capsule sparing
OT  - Intrafascial prostatectomy
OT  - Nerve sparing
OT  - Radical cystectomy
OT  - Sexual function
OT  - Urinary incontinence
EDAT- 2015/01/13 06:00
MHDA- 2016/07/20 06:00
CRDT- 2015/01/12 06:00
PHST- 2014/08/25 00:00 [received]
PHST- 2015/01/04 00:00 [accepted]
PHST- 2015/01/12 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2016/07/20 06:00 [medline]
AID - 10.1007/s00345-015-1482-y [pii]
AID - 10.1007/s00345-015-1482-y [doi]
PST - ppublish
SO  - World J Urol. 2015 Oct;33(10):1389-95. doi: 10.1007/s00345-015-1482-y. Epub 2015 
      Jan 11.