PMID- 25577775 OWN - NLM STAT- MEDLINE DCOM- 20160105 LR - 20220321 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 182 DP - 2015 Mar 1 TI - Plasma angiopoietin-1 level, left ventricular ejection fraction, and multivessel disease predict development of 1-year major adverse cardiovascular events in patients with acute ST elevation myocardial infarction - a pilot study. PG - 155-60 LID - S0167-5273(15)00021-2 [pii] LID - 10.1016/j.ijcard.2014.12.172 [doi] AB - OBJECTIVES: Patients with acute myocardial infarction (AMI) are frequently complicated with major cardiovascular events (MACEs). Endothelial dysfunction has been found to be involved in pathogenesis of AMI, but its role in development of MACEs after AMI is not clearly investigated. This study aimed to determine whether the plasma markers of endothelial dysfunction could serve as independent predictors for MACEs in patients with AMI. METHODS: This prospective study was conducted from March 2010 to July 2012 and enrolled consecutive 132 patients with acute ST elevation myocardial infarction (STEMI) receiving primary percutaneous coronary intervention (PCI). Plasma levels of thrombomodulin (TM), von Willebrand factor (vWF), angiopoietin (Ang)-1, Ang-2, Tie-2, and vascular endothelial growth factor (VEGF) were measured on day 1 of AMI. The development of MACEs at 1-year follow-up was recorded. RESULT: Patients with STEMI who developed MACEs had increased heart rate on admission (86+/-24 vs. 74+/-20bpm, p=0.006), lower left ventricular ejection fraction (LVEF) (49.0+/-12.4 vs. 57.2+/-12.4%, p=0.002), and higher incidence of multivessel disease (66.7% vs. 42.2%, p=0.018) comparing with those without MACEs. Plasma level of Ang-1 was lower in patients with MACEs than in those without (21,165+/-16,281 vs. 31,411+/-21,593pg/mL, p=0.018). In multivariate analysis, Ang-1 level