PMID- 25578258
OWN - NLM
STAT- MEDLINE
DCOM- 20151112
LR  - 20181202
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1601
DP  - 2015 Mar 19
TI  - Chronic all-trans retinoic acid administration induces CRF over-expression 
      accompanied by AVP up-regulation and multiple CRF-controlling receptors 
      disturbance in the hypothalamus of rats.
PG  - 1-7
LID - S0006-8993(15)00002-5 [pii]
LID - 10.1016/j.brainres.2014.12.054 [doi]
AB  - Clinical reports suggest a potential link between excess retinoids and 
      development of depression. Corticotropin-releasing factor (CRF) produced in the 
      hypothalamic paraventricular nucleus (PVN) is considered the central driver of 
      the hypothalamic-pituitary-adrenal (HPA) axis and plays a key role in the 
      pathogenesis of depression. Although we had shown that chronic all-trans retinoic 
      acid (ATRA) administration induced hypothalamic CRF over-expression and 
      hyperactivity of HPA axis in rats, further insight into how ATRA modulate CRF 
      expression is lacking. The activity of CRF neurons is under close control of 
      vasopressinergic system and three-paired receptors (corticosteroid receptors, sex 
      hormone receptors and CRF receptors). Here we show that ATRA-induced CRF 
      over-expression is accompanied by arginine-vasopressin (AVP) up-regulation and 
      apparent gene expression disturbances of CRF-controlling receptors. ATRA was 
      applied to rats by daily intraperitoneal injection for 6 weeks. Chronic ATRA 
      treatment induced significantly increased expression of CRF and AVP in the PVN. 
      Moreover, the transcript levels of CRF receptor 1 (CRFR1), estrogen receptor-beta 
      (ERbeta) and mineralocorticoid receptor (MR), three genes involved in the activation 
      of CRF neurons, were significantly increased in the hypothalamus, and the 
      expression ratio of GRalpha/MR was markedly decreased. Correlation analysis indicated 
      that the alteration of multiple CRF-controlling receptors is highly correlated 
      with depression-related behaviors of rats in the forced swimming test. These 
      findings support that in addition to the 'classic' retinoic acid receptor 
      alpha-mediated transcriptional control of CRF expression, disruption in 
      CRF-modulating systems constitutes a novel pathway that underlies ATRA-induced 
      HPA axis hyperactivity in vivo.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Cai, Li
AU  - Cai L
AD  - Department of Pathology, School of Basic Medicine, Anhui Medical University, 
      Hefei 230032, Anhui, China; Key Laboratory of Brain Function and Diseases, School 
      of Life Science, University of Science and Technology of China, Hefei 230027, 
      Anhui, China.
FAU - Li, Rong
AU  - Li R
AD  - School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China.
FAU - Zhou, Jiang-Ning
AU  - Zhou JN
AD  - Key Laboratory of Brain Function and Diseases, School of Life Science, University 
      of Science and Technology of China, Hefei 230027, Anhui, China. Electronic 
      address: jnzhou_ustc@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150108
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 0 (Receptors, Mineralocorticoid)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 5688UTC01R (Tretinoin)
RN  - 5CLY6W2H1M (CRF receptor type 1)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/*genetics
MH  - Corticosterone/blood
MH  - Corticotropin-Releasing Hormone/*metabolism
MH  - Depression/chemically induced/genetics/*metabolism
MH  - Disease Models, Animal
MH  - Estrogen Receptor beta/genetics
MH  - Gene Expression
MH  - Hypothalamus/*metabolism
MH  - Male
MH  - Motor Activity
MH  - Neurons/*metabolism
MH  - Paraventricular Hypothalamic Nucleus/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Corticotropin-Releasing Hormone/genetics
MH  - Receptors, Mineralocorticoid/genetics
MH  - Tretinoin/*administration & dosage
OTO - NOTNLM
OT  - All-trans retinoic acid
OT  - Arginine-vasopressin
OT  - Corticotrophin-releasing factor
OT  - Depression
OT  - Hypothalamic-pituitary-adrenal axis
OT  - Paired CRF-controlling receptor
EDAT- 2015/01/13 06:00
MHDA- 2015/11/13 06:00
CRDT- 2015/01/13 06:00
PHST- 2014/08/17 00:00 [received]
PHST- 2014/12/02 00:00 [revised]
PHST- 2014/12/31 00:00 [accepted]
PHST- 2015/01/13 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/11/13 06:00 [medline]
AID - S0006-8993(15)00002-5 [pii]
AID - 10.1016/j.brainres.2014.12.054 [doi]
PST - ppublish
SO  - Brain Res. 2015 Mar 19;1601:1-7. doi: 10.1016/j.brainres.2014.12.054. Epub 2015 
      Jan 8.