PMID- 25579246
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1885-1398 (Electronic)
IS  - 1699-258X (Linking)
VI  - 11
IP  - 3
DP  - 2015 May-Jun
TI  - Usefulness of antibodies and minor salivary gland biopsy in the study of sicca 
      syndrome in daily clinical practice.
PG  - 156-60
LID - S1699-258X(14)00131-4 [pii]
LID - 10.1016/j.reuma.2014.06.004 [doi]
AB  - OBJECTIVES: To assess the association between histologic findings in the minor 
      salivary gland biopsy (MSGB) and anti La (La/SS-B)y antiRo antibodies (Ro/SS-A), 
      antinuclear antibodies (ANA) and Rheumatoid Factor (RF),and compare the value of 
      the latter as diagnostic tests with MSGB, considered as the gold standard. 
      MATERIAL AND METHOD: Patients with suspected Primary Sjogren Syndrome (PSS) 
      referred for MSGB were included. Antibody measurements were performed. Grade III 
      and IV biopsy results were considered positive. RESULTS: Two hundred and eighteen 
      (218) patients were included, 95% females, with a median age of 54 years and 12 
      months median duration of sicca symptoms. 36 of the biopsies were positive. 33% 
      of patients had positive anti Ro/SS-A anti La/SS-B antibodies, 62% had positive 
      ANA, and 31% positive RF. A statistically significant association was found 
      between MSGB and anti Ro/SS-A anti La/SS-B, ANA and RF. ANA were the most 
      sensitive antibodies (84%. 95% CI: 75- 92), and the most specific were: Anti Ro/ 
      SS-A and/or anti La/ SS-B (78%. 95% CI: 71-85) and RF (78%. 95% CI: 69-87). 
      CONCLUSION: On PSS clinical suspicion, anti Ro/ SS-A y anti La/ SS-B antibodies 
      have a great value to achieve the diagnosis, with MSGB useful for diagnosis of 
      seronegative patients. The results also suggest the importance of ANA and RF for 
      PSS classification.
CI  - Copyright (c) 2015 Elsevier Espana, S.L.U. All rights reserved.
FAU - Santiago, Maria Lida
AU  - Santiago ML
AD  - Servicio de Reumatologia, Hospital General de Agudos Bernardino Rivadavia, Ciudad 
      Autonoma de Buenos Aires, Buenos Aires, Argentina. Electronic address: 
      lidasantiagor@yahoo.com.ar.
FAU - Seisdedos, Maria Renata
AU  - Seisdedos MR
AD  - Servicio de Reumatologia, Hospital General de Agudos Bernardino Rivadavia, Ciudad 
      Autonoma de Buenos Aires, Buenos Aires, Argentina.
FAU - Garcia Salinas, Rodrigo Nicolas
AU  - Garcia Salinas RN
AD  - Servicio de Reumatologia, Hospital General de Agudos Bernardino Rivadavia, Ciudad 
      Autonoma de Buenos Aires, Buenos Aires, Argentina.
FAU - Catalan Pellet, Antonio
AU  - Catalan Pellet A
AD  - Servicio de Reumatologia, Hospital General de Agudos Bernardino Rivadavia, Ciudad 
      Autonoma de Buenos Aires, Buenos Aires, Argentina.
FAU - Villalon, Liliana
AU  - Villalon L
AD  - Catedra de Anatomia Patologica, Facultad de Medicina, Universidad de Buenos 
      Aires, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina.
FAU - Secco, Anastasia
AU  - Secco A
AD  - Servicio de Reumatologia, Hospital General de Agudos Bernardino Rivadavia, Ciudad 
      Autonoma de Buenos Aires, Buenos Aires, Argentina.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20150109
PL  - Spain
TA  - Reumatol Clin
JT  - Reumatologia clinica
JID - 101293923
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Biomarkers)
RN  - 0 (SS-A antibodies)
RN  - 0 (SS-B antibodies)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Adult
MH  - Antibodies, Antinuclear/*blood
MH  - Biomarkers/blood
MH  - Biopsy
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Rheumatoid Factor/*blood
MH  - Salivary Glands, Minor/*pathology
MH  - Sensitivity and Specificity
MH  - Sjogren's Syndrome/blood/*diagnosis/immunology/pathology
OTO - NOTNLM
OT  - Anti La/SS-B
OT  - Anti Ro/SS-A
OT  - Biopsia de glandula salival
OT  - Complejo sicca
OT  - Salivary gland biopsy
OT  - Sicca complex
OT  - Sjogren
EDAT- 2015/01/13 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/01/13 06:00
PHST- 2014/02/12 00:00 [received]
PHST- 2014/06/02 00:00 [revised]
PHST- 2014/06/06 00:00 [accepted]
PHST- 2015/01/13 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1699-258X(14)00131-4 [pii]
AID - 10.1016/j.reuma.2014.06.004 [doi]
PST - ppublish
SO  - Reumatol Clin. 2015 May-Jun;11(3):156-60. doi: 10.1016/j.reuma.2014.06.004. Epub 
      2015 Jan 9.