PMID- 25579642
OWN - NLM
STAT- MEDLINE
DCOM- 20150513
LR  - 20220331
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 159
IP  - 4
DP  - 2015 Apr
TI  - Retinal and choroidal changes and visual outcome in central retinal artery 
      occlusion: an optical coherence tomography study.
PG  - 667-76
LID - S0002-9394(15)00005-7 [pii]
LID - 10.1016/j.ajo.2015.01.001 [doi]
AB  - PURPOSE: To investigate the retinal and choroidal changes using spectral-domain 
      optical coherence tomography (SD OCT) and to identify factors associated with 
      visual outcome in eyes with central retinal artery occlusion (CRAO). DESIGN: 
      Retrospective, observational case series. METHODS: setting: Institutional. 
      PATIENTS: A total of 134 eyes diagnosed with acute (symptom onset </= 7 days) 
      nonarteritic CRAO examined with SD OCT at baseline and follow-up visits. 
      OBSERVATIONS: Based on funduscopic and angiographic findings, CRAO was 
      categorized into 3 stages: incomplete, subtotal, and total. Abnormal morphologic 
      features were evaluated from SD OCT images. Central macular thickness (CMT), 
      inner and outer retinal thicknesses, and subfoveal choroidal thickness (SFCT) 
      were measured. The clinical and SD OCT features were correlated with the final 
      best-corrected visual acuities (BCVA). MAIN OUTCOME MEASURES: Retinal and 
      choroidal thickness and BCVA. RESULTS: Features of SD OCT at the initial 
      presentation included inner and outer retinal thickening. At baseline, the 
      frequency of inner and outer retinal thickening and macular edema (CMT > 300 mum) 
      differed significantly among CRAO stages (all P < .05). SFCT in eyes with total 
      CRAO was significantly thinner compared with that of the contralateral eyes (P = 
      .009). A higher CRAO stage was associated significantly with macular edema at 
      baseline (P < .001) and retinal thinning at the final visit (P = .010). Baseline 
      CMT was correlated significantly with final BCVA (P < .001). Multivariate 
      logistic regression analyses revealed that severe vision loss (BCVA < 20/200) was 
      associated significantly with CRAO stage (P < .001) and baseline CMT (P = .005). 
      CONCLUSIONS: CRAO resulted in inner and outer retinal thickening in the acute 
      stages and subsequent atrophic changes in the inner and outer retina. SD OCT may 
      be a useful noninvasive imaging tool for diagnosis, staging, and prognosis of 
      CRAO.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Ahn, Seong Joon
AU  - Ahn SJ
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, South Korea; Department of 
      Ophthalmology, Armed Forces Capital Hospital, Seongnam, South Korea.
FAU - Woo, Se Joon
AU  - Woo SJ
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, South Korea. Electronic address: 
      sejoon1@snu.ac.kr.
FAU - Park, Kyu Hyung
AU  - Park KH
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, South Korea.
FAU - Jung, Cheolkyu
AU  - Jung C
AD  - Department of Radiology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, South Korea.
FAU - Hong, Jeong-Ho
AU  - Hong JH
AD  - Department of Neurology, Keimyung University Dongsan Medical Center, Daegu, South 
      Korea; Department of Neurology, Seoul National University College of Medicine, 
      Seoul National University Bundang Hospital, Seongnam, South Korea.
FAU - Han, Moon-Ku
AU  - Han MK
AD  - Department of Neurology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, South Korea.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150109
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid/*pathology
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Macular Edema/classification/*diagnosis/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Retina/*pathology
MH  - Retinal Artery Occlusion/classification/*diagnosis/physiopathology
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/*physiology
EDAT- 2015/01/13 06:00
MHDA- 2015/05/15 06:00
CRDT- 2015/01/13 06:00
PHST- 2014/07/02 00:00 [received]
PHST- 2014/12/31 00:00 [revised]
PHST- 2015/01/01 00:00 [accepted]
PHST- 2015/01/13 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
AID - S0002-9394(15)00005-7 [pii]
AID - 10.1016/j.ajo.2015.01.001 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Apr;159(4):667-76. doi: 10.1016/j.ajo.2015.01.001. Epub 
      2015 Jan 9.