PMID- 25579644
OWN - NLM
STAT- MEDLINE
DCOM- 20150513
LR  - 20220408
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 159
IP  - 4
DP  - 2015 Apr
TI  - Fourier-domain optical coherence tomography imaging in corneal epithelial 
      basement membrane dystrophy: a structural analysis.
PG  - 755-63
LID - S0002-9394(15)00007-0 [pii]
LID - 10.1016/j.ajo.2015.01.003 [doi]
AB  - PURPOSE: To investigate the features of corneal epithelial basement membrane 
      dystrophy using spectral-domain optical coherence tomography (SD OCT) and to 
      examine the reliability of SD OCT in distinguishing epithelial basement membrane 
      dystrophy from the normal cornea. DESIGN: Diagnostic test study. METHODS: 
      Forty-five individuals with epithelial basement membrane dystrophy and 45 age- 
      and sex-matched controls with normal corneas were examined, and SD OCT scans of 
      their corneas were performed. In vivo confocal microscopy was performed to 
      confirm or rule out the diagnosis of epithelial basement membrane dystrophy. The 
      structural corneal changes occurring in eyes with epithelial basement membrane 
      dystrophy based on SD OCT findings were described. RESULTS: Epithelial 
      abnormalities were observed in 86 of 87 eyes with epithelial basement membrane 
      dystrophy (45 patients) on SD OCT scans. The 2 main features were the presence of 
      an irregular and thickened epithelial basement membrane duplicating or 
      insinuating into the corneal epithelium layer, or both, and the presence of 
      hyperreflective dots. In some cases, we detected hyporeflective spaces between 
      the corneal epithelial layer and the Bowman layer similar to a corneal epithelial 
      detachment. This corneal epithelial detachment sometimes was associated with a 
      cleavage with a stair-step appearance within the corneal epithelial layer. We 
      found a perfect correlation between in vivo confocal microscopy and SD OCT 
      findings in the diagnosis of epithelial basement membrane dystrophy (kappa = 0.98). 
      CONCLUSIONS: SD OCT provides an accurate assessment of the structural changes 
      occurring in eyes with epithelial basement membrane dystrophy. These changes, 
      visible on SD OCT scans, are easily detectable and permit an accurate diagnosis, 
      especially in patients with no biomicroscopically visible corneal changes.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - El Sanharawi, Mohamed
AU  - El Sanharawi M
AD  - Department of Ophthalmology V, Quinze-Vingts National Ophthalmology Hospital, 
      Paris, France. Electronic address: mohamed.elsanharawi@gmail.com.
FAU - Sandali, Otman
AU  - Sandali O
AD  - Department of Ophthalmology V, Quinze-Vingts National Ophthalmology Hospital, 
      Paris, France.
FAU - Basli, Elena
AU  - Basli E
AD  - Department of Ophthalmology V, Quinze-Vingts National Ophthalmology Hospital, 
      Paris, France.
FAU - Bouheraoua, Nacim
AU  - Bouheraoua N
AD  - Department of Ophthalmology V, Quinze-Vingts National Ophthalmology Hospital, 
      Paris, France.
FAU - Ameline, Barbara
AU  - Ameline B
AD  - Department of Ophthalmology V, Quinze-Vingts National Ophthalmology Hospital, 
      Paris, France.
FAU - Goemaere, Isabelle
AU  - Goemaere I
AD  - Department of Ophthalmology V, Quinze-Vingts National Ophthalmology Hospital, 
      Paris, France.
FAU - Georgeon, Cristina
AU  - Georgeon C
AD  - Department of Ophthalmology V, Quinze-Vingts National Ophthalmology Hospital, 
      Paris, France.
FAU - Hamiche, Taous
AU  - Hamiche T
AD  - Department of Ophthalmology V, Quinze-Vingts National Ophthalmology Hospital, 
      Paris, France.
FAU - Borderie, Vincent
AU  - Borderie V
AD  - Department of Ophthalmology V, Quinze-Vingts National Ophthalmology Hospital, 
      Paris, France.
FAU - Laroche, Laurent
AU  - Laroche L
AD  - Department of Ophthalmology V, Quinze-Vingts National Ophthalmology Hospital, 
      Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20150109
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - Corneal dystrophy, epithelial basement membrane
SB  - IM
MH  - Adult
MH  - Aged
MH  - Basement Membrane/pathology
MH  - Cogan Syndrome/*diagnosis
MH  - Epithelium, Corneal/pathology
MH  - Female
MH  - Fourier Analysis
MH  - Humans
MH  - Male
MH  - Microscopy, Confocal
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Young Adult
EDAT- 2015/01/13 06:00
MHDA- 2015/05/15 06:00
CRDT- 2015/01/13 06:00
PHST- 2014/10/13 00:00 [received]
PHST- 2015/01/02 00:00 [revised]
PHST- 2015/01/06 00:00 [accepted]
PHST- 2015/01/13 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
AID - S0002-9394(15)00007-0 [pii]
AID - 10.1016/j.ajo.2015.01.003 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Apr;159(4):755-63. doi: 10.1016/j.ajo.2015.01.003. Epub 
      2015 Jan 9.