PMID- 25580665
OWN - NLM
STAT- MEDLINE
DCOM- 20160101
LR  - 20221207
IS  - 1463-1326 (Electronic)
IS  - 1462-8902 (Linking)
VI  - 17
IP  - 5
DP  - 2015 May
TI  - Effect of subcutaneous insulin detemir on glucose flux and lipolysis during 
      hyperglycaemia in people with type 1 diabetes.
PG  - 459-67
LID - 10.1111/dom.12434 [doi]
AB  - AIMS: To investigate, using a novel non-steady-state protocol, the differential 
      effects of subcutaneous (s.c.) detemir and NPH insulin on glucose flux and lipid 
      metabolism after insulin withdrawal. METHODS: After a period of insulin 
      withdrawal resulting in whole-blood glucose concentration of 7 mmol/l, 11 
      participants (five men, mean age 41.0 years, mean body mass index 25 kg/m(2)) 
      with type 1 diabetes (mean glycated haemoglobin concentration 57 mmol/mol, mean 
      diabetes duration 14 years) received 0.5 units per kg body weight s.c. insulin 
      detemir or NPH insulin in random order. Stable isotopes of glucose and glycerol 
      were infused intravenously throughout the study protocol. RESULTS: Glucose 
      concentration decreased after insulin treatment as a result of suppression of 
      endogenous glucose production, which occurred to a similar extent with both 
      detemir and NPH insulin. The rate of glucose disappearance (Rd) was not increased 
      significantly with either type of insulin. When the effect of detemir and NPH 
      insulin on glucose flux at glucose concentrations between 9 and 6 mmol/l was 
      examined, glucose rate of appearance (Ra) was similar with the two insulins; 
      however, glucose Rd was greater with NPH insulin than with detemir at glucose 
      concentrations of 8.0, 8.5, 7.0 and 6.0 mmol/l (p < 0.05) The percentage change 
      in glycerol Ra, a measure of lipolysis, was greater in the NPH group than in the 
      detemir group (p = 0.04). CONCLUSIONS: The results of the study are consistent 
      with the hypothesis that detemir has a lesser effect on the periphery, as 
      evidenced by a lesser effect on peripheral glucose uptake at specific glucose 
      concentrations.
CI  - (c) 2015 John Wiley & Sons Ltd.
FAU - Herring, R A
AU  - Herring RA
AD  - Centre for Endocrinology, Diabetes and Research, Royal Surrey County Hospital, 
      Guildford, UK; Diabetes and Metabolic Medicine, Faculty of Health and Medical 
      Sciences, University of Surrey Leggett Building, Daphne Jackson Rd, Manor Park, 
      Guildford GU2 7WG, UK.
FAU - Shojaee-Moradie, F
AU  - Shojaee-Moradie F
FAU - Umpleby, A M
AU  - Umpleby AM
FAU - Jones, R
AU  - Jones R
FAU - Jackson, N
AU  - Jackson N
FAU - Russell-Jones, D L
AU  - Russell-Jones DL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150201
PL  - England
TA  - Diabetes Obes Metab
JT  - Diabetes, obesity & metabolism
JID - 100883645
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 4FT78T86XV (Insulin Detemir)
RN  - 53027-39-7 (Insulin, Isophane)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Adult
MH  - Blood Glucose/biosynthesis/*drug effects
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 1/*drug therapy
MH  - Glycated Hemoglobin
MH  - Glycerol/blood
MH  - Humans
MH  - Hyperglycemia/*drug therapy
MH  - Hypoglycemic Agents/administration & dosage/*pharmacology
MH  - Injections, Subcutaneous
MH  - Insulin Detemir/administration & dosage/*pharmacology
MH  - Insulin, Isophane/pharmacology
MH  - Lipolysis/*drug effects
MH  - Male
OTO - NOTNLM
OT  - insulin analogues
OT  - insulin therapy
OT  - liver
OT  - type 1 diabetes
EDAT- 2015/01/13 06:00
MHDA- 2016/01/02 06:00
CRDT- 2015/01/13 06:00
PHST- 2014/10/16 00:00 [received]
PHST- 2014/12/19 00:00 [revised]
PHST- 2015/01/03 00:00 [accepted]
PHST- 2015/01/13 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2016/01/02 06:00 [medline]
AID - 10.1111/dom.12434 [doi]
PST - ppublish
SO  - Diabetes Obes Metab. 2015 May;17(5):459-67. doi: 10.1111/dom.12434. Epub 2015 Feb 
      1.