PMID- 25580989
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20181202
IS  - 1463-1318 (Electronic)
IS  - 1462-8910 (Linking)
VI  - 17
IP  - 4
DP  - 2015 Apr
TI  - Postoperative analgesia with continuous wound infusion of local anaesthesia vs 
      saline: a double-blind randomized, controlled trial in colorectal surgery.
PG  - 342-50
LID - 10.1111/codi.12893 [doi]
AB  - AIM: The aim of this prospective double-blind randomized clinical trial was to 
      determine whether preperitoneal continuous wound infusion (CWI) of the local 
      anaesthetic ropivacaine after either laparotomy or video-assisted laparoscopy for 
      colorectal surgery would reduce patient consumption of morphine. METHOD: Patients 
      scheduled for colorectal surgery randomly received a 48-h preperitoneal CWI of 
      either 0.38% ropivacaine or 0.9% saline at rates of 5 ml/h after laparotomy or 
      2 ml/h after laparoscopy. The primary end-point was total morphine consumption in 
      surgery and afterwards through a patient-controlled analgesia device. Results in 
      the laparotomy and laparoscopy subgroups were also compared. RESULTS: Sixty-seven 
      patients were included, 33 in the ropivacaine CWI group and 34 in the saline 
      group. Median [interquartile range (IQR)] morphine consumption was lower in the 
      ropivacaine group [23.5 mg (11.25-42.75)] than in the saline group [52 mg 
      (24.5-64)] (P = 0.010). Morphine consumption was also lower in the laparotomy 
      subgroup receiving ropivacaine [21.5 (15.6-34.7)] than in the saline group [52.5 
      (22.5-65) ml] (P = 0.041). Consumption was statistically similar in laparoscopy 
      patients on ropivacaine or saline. No side effects were observed. Sixteen 
      patients had a surgical wound infection (23.9%); 11 (16.4%) presented wound 
      infection and five (7.5%) organ space infection. Forty-six catheter cultures were 
      obtained; 10 (21.7%) were positive, assessed to be due to contamination. 
      CONCLUSION: Preperitoneal CWI of ropivacaine is a good, safe addition to a 
      multimodal analgesia regimen for colorectal surgery. CWI can reduce morphine 
      consumption without increasing adverse effects.
CI  - Colorectal Disease (c) 2015 The Association of Coloproctology of Great Britain and 
      Ireland.
FAU - Fustran, N
AU  - Fustran N
AD  - Department of Anaesthesia, Reanimation and Pain Clinic, Bellvitge University 
      Hospital, University of Barcelona, Barcelona, Spain.
FAU - Dalmau, A
AU  - Dalmau A
FAU - Ferreres, E
AU  - Ferreres E
FAU - Camprubi, I
AU  - Camprubi I
FAU - Sanzol, R
AU  - Sanzol R
FAU - Redondo, S
AU  - Redondo S
FAU - Kreisler, E
AU  - Kreisler E
FAU - Biondo, S
AU  - Biondo S
FAU - Sabate, A
AU  - Sabate A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Colorectal Dis
JT  - Colorectal disease : the official journal of the Association of Coloproctology of 
      Great Britain and Ireland
JID - 100883611
RN  - 0 (Amides)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 76I7G6D29C (Morphine)
RN  - 7IO5LYA57N (Ropivacaine)
SB  - IM
CIN - Colorectal Dis. 2015 Nov;17(11):1028-9. PMID: 26250470
CIN - Colorectal Dis. 2015 Nov;17(11):1028. PMID: 26291825
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amides
MH  - Analgesics, Opioid/*therapeutic use
MH  - Anesthetics, Local/*therapeutic use
MH  - *Colectomy
MH  - Digestive System Surgical Procedures
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Infusions, Intralesional
MH  - Laparoscopy
MH  - Laparotomy
MH  - Male
MH  - Middle Aged
MH  - Morphine/*therapeutic use
MH  - Pain Management/*methods
MH  - Pain, Postoperative/*drug therapy
MH  - Postoperative Care/methods
MH  - Rectum/*surgery
MH  - Ropivacaine
MH  - Sodium Chloride
MH  - *Surgical Wound Infection
MH  - Young Adult
OTO - NOTNLM
OT  - Wound analgesia
OT  - laparoscopy
OT  - laparotomy
OT  - local anaesthesia
OT  - pain
EDAT- 2015/01/13 06:00
MHDA- 2015/12/17 06:00
CRDT- 2015/01/13 06:00
PHST- 2014/06/11 00:00 [received]
PHST- 2014/08/18 00:00 [accepted]
PHST- 2015/01/13 06:00 [entrez]
PHST- 2015/01/13 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
AID - 10.1111/codi.12893 [doi]
PST - ppublish
SO  - Colorectal Dis. 2015 Apr;17(4):342-50. doi: 10.1111/codi.12893.