PMID- 25586651
OWN - NLM
STAT- MEDLINE
DCOM- 20150928
LR  - 20220330
IS  - 1435-5922 (Electronic)
IS  - 0944-1174 (Linking)
VI  - 50
IP  - 2
DP  - 2015 Feb
TI  - Evidence-based clinical practice guidelines for functional dyspepsia.
PG  - 125-39
LID - 10.1007/s00535-014-1022-3 [doi]
AB  - General interest in functional gastrointestinal disorders is increasing among 
      Japanese doctors as well as patients. This increase can be attributed to a number 
      of factors, including recent increased interest in quality of life and advances 
      in our understanding of the pathophysiology of gastrointestinal disease. Japan 
      recently became the world's first country to list "functional dyspepsia" as a 
      disease name for national insurance billing purposes. However, recognition and 
      understanding of functional dyspepsia (FD) remain poor, and no standard treatment 
      strategy has yet been established. Accordingly, the Japanese Society of 
      Gastroenterology (JSGE) developed an evidence-based clinical practice guideline 
      for FD, consisting of five sections: concept, definition, and epidemiology; 
      pathophysiology; diagnosis; treatment; and prognosis and complications. This 
      article summarizes the Japanese guideline, with particular focus on the treatment 
      section. Once a patient is diagnosed with FD, the doctor should carefully explain 
      the pathophysiology and benign nature of this condition, establish a good 
      doctor-patient relationship, and then provide advice for daily living (diet and 
      lifestyle modifications, explanations, and reassurance). The proposed 
      pharmacological treatment is divided into two steps: initial treatment including 
      an acid inhibitory drug (H2RA or PPI) or prokinetics, (strong recommendation); 
      second-line treatment including anxiolytics, antidepressants, and Japanese 
      traditional medicine (weak recommendation). H. pylori eradication, strongly 
      recommended with a high evidence level, is positioned separately from other 
      treatment flows. Conditions that do not respond to these treatment regimens are 
      regarded as refractory FD. Patients will be further examined for other organic 
      disorders or will be referred to specialists using other approaches such as 
      psychosomatic treatment.
FAU - Miwa, Hiroto
AU  - Miwa H
AD  - Guidelines Committee for creating and evaluating the "Evidence-based clinical 
      practice guidelines for functional dyspepsia", the Japanese Society of 
      Gastroenterology (JSGE), K-18 Building 8F, 8-9-13 Ginza, Chuo, Tokyo, 104-0061, 
      Japan, miwahgi@hyo-med.ac.jp.
FAU - Kusano, Motoyasu
AU  - Kusano M
FAU - Arisawa, Tomiyasu
AU  - Arisawa T
FAU - Oshima, Tadayuki
AU  - Oshima T
FAU - Kato, Mototsugu
AU  - Kato M
FAU - Joh, Takashi
AU  - Joh T
FAU - Suzuki, Hidekazu
AU  - Suzuki H
FAU - Tominaga, Kazunari
AU  - Tominaga K
FAU - Nakada, Koji
AU  - Nakada K
FAU - Nagahara, Akihito
AU  - Nagahara A
FAU - Futagami, Seiji
AU  - Futagami S
FAU - Manabe, Noriaki
AU  - Manabe N
FAU - Inui, Akio
AU  - Inui A
FAU - Haruma, Ken
AU  - Haruma K
FAU - Higuchi, Kazuhide
AU  - Higuchi K
FAU - Yakabi, Koji
AU  - Yakabi K
FAU - Hongo, Michio
AU  - Hongo M
FAU - Uemura, Naomi
AU  - Uemura N
FAU - Kinoshita, Yoshikazu
AU  - Kinoshita Y
FAU - Sugano, Kentaro
AU  - Sugano K
FAU - Shimosegawa, Tooru
AU  - Shimosegawa T
CN  - Japanese Society of Gastroenterology
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PT  - Research Support, Non-U.S. Gov't
DEP - 20150114
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
RN  - 0 (Gastrointestinal Agents)
SB  - IM
MH  - Algorithms
MH  - Complementary Therapies/methods
MH  - Diagnostic Techniques, Digestive System
MH  - Dyspepsia/*diagnosis/*drug therapy/epidemiology/physiopathology
MH  - Evidence-Based Medicine/methods
MH  - Gastrointestinal Agents/therapeutic use
MH  - Humans
MH  - Prevalence
MH  - Prognosis
MH  - Terminology as Topic
EDAT- 2015/01/15 06:00
MHDA- 2015/09/29 06:00
CRDT- 2015/01/15 06:00
PHST- 2014/11/14 00:00 [received]
PHST- 2014/11/20 00:00 [accepted]
PHST- 2015/01/15 06:00 [entrez]
PHST- 2015/01/15 06:00 [pubmed]
PHST- 2015/09/29 06:00 [medline]
AID - 10.1007/s00535-014-1022-3 [doi]
PST - ppublish
SO  - J Gastroenterol. 2015 Feb;50(2):125-39. doi: 10.1007/s00535-014-1022-3. Epub 2015 
      Jan 14.