PMID- 25587206
OWN - NLM
STAT- MEDLINE
DCOM- 20150731
LR  - 20220331
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2014
DP  - 2014
TI  - Stepwise application of urine markers to detect tumor recurrence in patients 
      undergoing surveillance for non-muscle-invasive bladder cancer.
PG  - 973406
LID - 10.1155/2014/973406 [doi]
LID - 973406
AB  - BACKGROUND: The optimal use of urine markers in the surveillance of 
      non-muscle-invasive bladder cancer (NMIBC) remains unclear. Aim of the present 
      study was to investigate the combined and stepwise use of the four most broadly 
      available urine markers to detect tumor recurrence in patients undergoing 
      surveillance of NMIBC. PATIENTS AND METHODS: 483 patients with history of NMIBC 
      were included. Cytology, UroVysion, fluorescence in situ hybridization (FISH), 
      immunocytology (uCyt+), and NMP22 ELISA were performed before surveillance 
      cystoscopy. Characteristics of single tests and combinations were assessed by 
      contingency analysis. RESULTS: 128 (26.5%) patients had evidence of tumor 
      recurrence. Sensitivities and negative predictive values (NPVs) of the single 
      tests ranged between 66.4-74.3 and 82.3-88.2%. Two-marker combinations showed 
      sensitivities and NPVs of 80.5-89.8 and 89.5-91.2%. A stepwise application of the 
      two-test combinations with highest accuracy (cytology and FISH; cytology and 
      uCyt+; uCyt+ and FISH) showed NPVs for high-risk recurrences (G3/Cis/pT1) of 
      98.8, 98.8, and 99.1%, respectively. CONCLUSIONS: Combinations of cytology, FISH, 
      immunocytology, and NMP22 show remarkable detection rates for recurrent NMIBC. 
      Stepwise two-test combinations of cytology, FISH, and immunocytology have a low 
      probability of missing a high-risk tumor. The high sensitivities may justify the 
      use of these combinations in prospective studies assessing the use of urine 
      markers to individualize intervals between cystoscopies during follow-up.
FAU - Todenhofer, Tilman
AU  - Todenhofer T
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany ; V6H 3Z6 Vancouver Prostate Centre, University of British 
      Columbia, 2660 Oak Street, Vancouver, BC, Canada V6H 3Z6.
FAU - Hennenlotter, Jorg
AU  - Hennenlotter J
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany.
FAU - Esser, Michael
AU  - Esser M
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany.
FAU - Mohrhardt, Sarah
AU  - Mohrhardt S
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany.
FAU - Aufderklamm, Stefan
AU  - Aufderklamm S
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany.
FAU - Bottge, Johannes
AU  - Bottge J
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany.
FAU - Rausch, Steffen
AU  - Rausch S
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany.
FAU - Mischinger, Johannes
AU  - Mischinger J
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany.
FAU - Bier, Simone
AU  - Bier S
AUID- ORCID: 0000-0003-0189-1119
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany.
FAU - Gakis, Georgios
AU  - Gakis G
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany.
FAU - Kuehs, Ursula
AU  - Kuehs U
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany.
FAU - Stenzl, Arnulf
AU  - Stenzl A
AUID- ORCID: 0000-0003-4207-9928
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany.
FAU - Schwentner, Christian
AU  - Schwentner C
AD  - Department of Urology, Eberhard-Karls University, Hoppe-Seyler Strasse 3, 72076 
      Tubingen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20141222
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*urine
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/diagnosis/*urine
MH  - Sensitivity and Specificity
MH  - Urinary Bladder Neoplasms/pathology/*urine
PMC - PMC4284969
EDAT- 2015/01/15 06:00
MHDA- 2015/08/01 06:00
PMCR- 2014/12/22
CRDT- 2015/01/15 06:00
PHST- 2014/09/11 00:00 [received]
PHST- 2014/12/05 00:00 [accepted]
PHST- 2015/01/15 06:00 [entrez]
PHST- 2015/01/15 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
PHST- 2014/12/22 00:00 [pmc-release]
AID - 10.1155/2014/973406 [doi]
PST - ppublish
SO  - Dis Markers. 2014;2014:973406. doi: 10.1155/2014/973406. Epub 2014 Dec 22.