PMID- 25587209
OWN - NLM
STAT- MEDLINE
DCOM- 20150908
LR  - 20181113
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2014
DP  - 2014
TI  - Brain-derived neurotrophic factor in chronic periodontitis.
PG  - 373765
LID - 10.1155/2014/373765 [doi]
LID - 373765
AB  - Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor 
      family. Outside the nervous system, BDNF has been shown to be expressed in 
      various nonneural tissues, such as periodontal ligament, dental pulp, and 
      odontoblasts. Although a role for BDNF in periodontal regeneration has been 
      suggested, a function for BDNF in periodontal disease has not yet been studied. 
      The aim of this study was to analyze the BDNF levels in periodontal tissues of 
      patients with chronic periodontitis (CP) and periodontally healthy controls (HC). 
      All subjects were genotyped for the rs4923463 and rs6265 BDNF polymorphisms. 
      Periodontal tissues were collected for ELISA, myeloperoxidase (MPO), and 
      microscopic analysis from 28 CP patients and 29 HC subjects. BDNF levels were 
      increased in CP patients compared to HC subjects. A negative correlation was 
      observed when analyzing concentration of BDNF and IL-10 in inflamed periodontium. 
      No differences in frequencies of BDNF genotypes between CP and HC subjects were 
      observed. However, BDNF genotype GG was associated with increased levels of BDNF, 
      TNF-alpha, and CXCL10 in CP patients. In conclusion, BDNF seems to be associated with 
      periodontal disease process, but the specific role of BDNF still needs to be 
      clarified.
FAU - Correa, Joice Dias
AU  - Correa JD
AD  - Department of Oral Surgery and Pathology, School of Dentistry, Federal University 
      of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, 
      Brazil.
FAU - Pereira, Daniele Sirineu
AU  - Pereira DS
AD  - Department of Physical Therapy, School of Physical Education, Physical Therapy 
      and Occupational Therapy, Federal University of Minas Gerais, Antonio Carlos 
      Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil.
FAU - Madeira, Mila Fernandes Moreira
AU  - Madeira MF
AD  - Department of Oral Surgery and Pathology, School of Dentistry, Federal University 
      of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, 
      Brazil.
FAU - Queiroz-Junior, Celso Martins
AU  - Queiroz-Junior CM
AD  - Department of Oral Surgery and Pathology, School of Dentistry, Federal University 
      of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, 
      Brazil.
FAU - Souza, Danielle Gloria
AU  - Souza DG
AD  - Department of Microbiology, Biological Sciences Institute, Federal University of 
      Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil.
FAU - Teixeira, Mauro Martins
AU  - Teixeira MM
AD  - Department of Biochemistry and Immunology, Biological Sciences Institute, Federal 
      University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo 
      Horizonte, MG, Brazil.
FAU - Costa, Jose Eustaquio
AU  - Costa JE
AD  - Department of Oral Surgery and Pathology, School of Dentistry, Federal University 
      of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, 
      Brazil.
FAU - Teixeira, Antonio Lucio
AU  - Teixeira AL
AD  - Department of Clinical Medicine, Faculty of Medicine, Federal University of Minas 
      Gerais, Professor Alfredo Balena Avenue 110, 30130-100 Belo Horizonte, MG, 
      Brazil.
FAU - da Silva, Tarcilia Aparecida
AU  - da Silva TA
AD  - Department of Oral Surgery and Pathology, School of Dentistry, Federal University 
      of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, 
      Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141221
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (IL10 protein, human)
RN  - 130068-27-8 (Interleukin-10)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - *Gene Expression Regulation
MH  - Genotype
MH  - Humans
MH  - Inflammation
MH  - Interleukin-10/metabolism
MH  - Male
MH  - Middle Aged
MH  - Periodontitis/*metabolism
MH  - Peroxidase/genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Sequence Analysis, DNA
PMC - PMC4283396
EDAT- 2015/01/15 06:00
MHDA- 2015/09/09 06:00
PMCR- 2014/12/21
CRDT- 2015/01/15 06:00
PHST- 2014/07/22 00:00 [received]
PHST- 2014/12/07 00:00 [accepted]
PHST- 2015/01/15 06:00 [entrez]
PHST- 2015/01/15 06:00 [pubmed]
PHST- 2015/09/09 06:00 [medline]
PHST- 2014/12/21 00:00 [pmc-release]
AID - 10.1155/2014/373765 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2014;2014:373765. doi: 10.1155/2014/373765. Epub 2014 Dec 21.