PMID- 25587326
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150114
LR  - 20201001
IS  - 1735-0328 (Print)
IS  - 1726-6890 (Electronic)
IS  - 1726-6882 (Linking)
VI  - 13
IP  - 4
DP  - 2014 Fall
TI  - Protective Effects of Lindera coreana on UVB-induced Oxidative Stress in Human 
      HaCaT Keratinocytes.
PG  - 1369-78
AB  - The present study was designed to investigate the protective effect of ethanol 
      extracts from Lindera coreana leaves (LCE) on UVB-induced oxidative stress in 
      HaCaT keratinocytes. The HaCaT cells were pretreated with LCE for 24 h and then 
      exposed to UVB (20 mJ/cm(2)) for 2 h. UVB significantly decreased the cell 
      viability (p<0.05). LCE did not exhibit significantly cytotoxic effects and 
      increased the viability of the HaCaT cells in a concentration-dependent manner. 
      To further investigate the protective effects of LCE on UVB-induced oxidative 
      stress in HaCaT cells, the cellular levels of reactive oxygen species (ROS), 
      lipid peroxidation and endogenous antioxidant enzymes, including catalase (CAT), 
      superoxide dismutase (SOD) and glutathione peroxidase (GSH-px), were analyzed. 
      LCE decreased the intracellular levels of ROS and lipid peroxidation and 
      increased the activity of antioxidant enzymes. These results suggest that LCE 
      exerted cytoprotective activity against UVB-induced oxidative stress in HaCaT 
      cells through the inhibition of lipid peroxidation, reduction of ROS levels and 
      stimulation of antioxidant enzymes activities. In addition, LCE also decreased 
      the TNF-alpha, IL-1beta and IL-6 levels in UVB-irradiated HaCaT cells.
FAU - Song, Jia-Le
AU  - Song JL
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Guilin Medical 
      University, People's Republic of China. ; Department of Food Science and 
      Nutrition, Pusan National University, Busan 609-735, South Korea.
FAU - Gao, Yang
AU  - Gao Y
AD  - Department of Pharmacy, Northern Jiangsu People's Hospital Affiliated to Yangzhou 
      University (Clinical Medical College of Yangzhou University), Yangzhou, Jiangsu 
      225001,People's Republic of China.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Iran J Pharm Res
JT  - Iranian journal of pharmaceutical research : IJPR
JID - 101208407
PMC - PMC4232803
OTO - NOTNLM
OT  - Antioxidant enzymes
OT  - HaCaT keratinocytes
OT  - Lindera coreana
OT  - Reactive oxygen species (ROS)
OT  - Ultraviolet (UV)
EDAT- 2015/01/15 06:00
MHDA- 2015/01/15 06:01
PMCR- 2014/09/01
CRDT- 2015/01/15 06:00
PHST- 2015/01/15 06:00 [entrez]
PHST- 2015/01/15 06:00 [pubmed]
PHST- 2015/01/15 06:01 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - ijpr-13-1369 [pii]
PST - ppublish
SO  - Iran J Pharm Res. 2014 Fall;13(4):1369-78.