PMID- 25587547
OWN - NLM
STAT- MEDLINE
DCOM- 20150707
LR  - 20220310
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2014
DP  - 2014
TI  - Relationship between levels of brain-derived neurotrophic factor and metabolic 
      parameters in patients with type 2 diabetes mellitus.
PG  - 978143
LID - 10.1155/2014/978143 [doi]
LID - 978143
AB  - BACKGROUND AND AIM: Studies have suggested that brain-derived neurotrophic factor 
      (BDNF) plays a role in glucose and lipid metabolism and inflammation. The aim of 
      this study was to evaluate the relationship between serum BDNF levels and various 
      metabolic parameters and inflammatory markers in patients with type 2 diabetes 
      mellitus (T2DM). MATERIALS AND METHODS: The study included 88 T2DM patients and 
      33 healthy controls. Fasting blood samples were obtained from the patients and 
      the control group. The serum levels of BDNF were measured with an ELISA kit. The 
      current paper introduces a receiver-operating characteristic (ROC) generalization 
      curve to identify cut-off for the BDNF values in type 2 diabetes patients. 
      RESULTS: The serum levels of BDNF were significantly higher in T2DM patients than 
      in the healthy controls (206.81 +/- 107.32 pg/mL versus 130.84 +/- 59.81 pg/mL; P < 
      0.001). They showed a positive correlation with the homeostasis model assessment 
      of insulin resistance (HOMA-IR) (r = 0.28; P < 0.05), the triglyceride level (r = 
      0.265; P < 0.05), and white blood cell (WBC) count (r = 0.35; P < 0.001). In 
      logistic regression analysis, age (P < 0.05), body mass index (BMI) (P < 0.05), 
      C-reactive protein (CRP) (P < 0.05), and BDNF (P < 0.01) were independently 
      associated with T2DM. In ROC curve analysis, BDNF cut-off was 137. CONCLUSION: 
      The serum BDNF level was higher in patients with T2DM. The BDNF had a cut-off 
      value of 137. The findings suggest that BDNF may contribute to glucose and lipid 
      metabolism and inflammation.
FAU - Boyuk, Banu
AU  - Boyuk B
AD  - Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research 
      Hospital, Siraselviler Caddesi No. 112, 34433 Istanbul, Turkey.
FAU - Degirmencioglu, Serife
AU  - Degirmencioglu S
AD  - Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research 
      Hospital, Siraselviler Caddesi No. 112, 34433 Istanbul, Turkey.
FAU - Atalay, Hande
AU  - Atalay H
AD  - Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research 
      Hospital, Siraselviler Caddesi No. 112, 34433 Istanbul, Turkey.
FAU - Guzel, Savas
AU  - Guzel S
AD  - Department of Biochemistry, Namik Kemal University, Turkey.
FAU - Acar, Ayse
AU  - Acar A
AD  - Department of Biochemistry, Namik Kemal University, Turkey.
FAU - Celebi, Aslan
AU  - Celebi A
AD  - Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research 
      Hospital, Siraselviler Caddesi No. 112, 34433 Istanbul, Turkey.
FAU - Ekizoglu, Ismail
AU  - Ekizoglu I
AD  - Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research 
      Hospital, Siraselviler Caddesi No. 112, 34433 Istanbul, Turkey.
FAU - Simsek, Caglar
AU  - Simsek C
AD  - Department of Diabetic Patient Education and Care Policlinic, Gaziosmanpasa 
      Taksim Education and Research Hospital, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20141222
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Area Under Curve
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Leukocyte Count
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Risk Factors
MH  - Triglycerides/blood
MH  - Up-Regulation
PMC - PMC4283269
EDAT- 2015/01/15 06:00
MHDA- 2015/07/08 06:00
PMCR- 2014/12/22
CRDT- 2015/01/15 06:00
PHST- 2014/11/01 00:00 [received]
PHST- 2014/12/08 00:00 [revised]
PHST- 2014/12/09 00:00 [accepted]
PHST- 2015/01/15 06:00 [entrez]
PHST- 2015/01/15 06:00 [pubmed]
PHST- 2015/07/08 06:00 [medline]
PHST- 2014/12/22 00:00 [pmc-release]
AID - 10.1155/2014/978143 [doi]
PST - ppublish
SO  - J Diabetes Res. 2014;2014:978143. doi: 10.1155/2014/978143. Epub 2014 Dec 22.