PMID- 2558777
OWN - NLM
STAT- MEDLINE
DCOM- 19900314
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 503
IP  - 1
DP  - 1989 Nov 27
TI  - Non-N-methyl-D-aspartate receptors may mediate ipsilateral excitation at lateral 
      superior olivary synapses.
PG  - 83-90
AB  - Principal cells of the lateral superior olivary nucleus (LSO) are thought to 
      receive a direct excitatory input from spherical bushy cells located in the 
      ipsilateral ventral cochlear nucleus (VCN) and an indirect input from the 
      contralateral VCN globular bushy cells via a secure synapse in the medial nucleus 
      of the trapezoid body (MNTB). MNTB bushy cells project to the somata and proximal 
      dendrites of LSO principal cells. LSO neurons display phasic 'chopper' temporal 
      response patterns to ipsilateral tone-burst stimuli at characteristic frequency 
      (CF), while binaural stimuli suppress this ipsilaterally evoked activity. This 
      suppression is sensitive to interaural differences in intensity, phase and time, 
      suggesting a role for these neurons in the localization of sound in space. In the 
      present study, the nature of the neurotransmitter mediating fast ipsilateral 
      excitation of LSO neurons was examined using iontophoretic application of 
      excitant amino acid (EAA) agonists and antagonists. N-methyl-D-aspartate (NMDA) 
      and quisqualate (QUIS) were used as agonists, while the selective NMDA receptor 
      antagonist D. L-2-amino-5-phosphonovaleric acid (APV), and the non-selective 
      receptor EAA antagonist cis-2,3-piperidine-dicarboxylic acid (PDA) were used to 
      study ipsilaterally evoked neuronal responses. In 3 additional experiments the 
      selective non-NMDA receptor antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX) 
      replaced PDA. Ipsilateral, tone-evoked and spontaneous activities were generally 
      enhanced by EAA agonists while partial blockade of tone-evoked, ipsilateral 
      excitation was observed with EAA antagonists. Both PDA and DNQX more effectively 
      blocked ipsilateral tone-evoked excitations and spontaneous activity than did the 
      NMDA-receptor antagonist, APV.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Caspary, D M
AU  - Caspary DM
AD  - Southern Illinois University, School of Medicine, Springfield 62794-9230.
FAU - Faingold, C L
AU  - Faingold CL
LA  - eng
GR  - NS 15640/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Oxadiazoles)
RN  - 0 (Receptors, Amino Acid)
RN  - 0 (Receptors, Cell Surface)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Acoustic Stimulation
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Aspartic Acid/analogs & derivatives/pharmacology
MH  - Auditory Pathways/*physiology
MH  - Chinchilla/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Functional Laterality/*physiology
MH  - Kainic Acid/*pharmacology
MH  - N-Methylaspartate
MH  - Olivary Nucleus/drug effects/metabolism/*physiology
MH  - Oxadiazoles/*pharmacology
MH  - Quisqualic Acid
MH  - Receptors, Amino Acid
MH  - Receptors, Cell Surface/drug effects/*physiology
EDAT- 1989/11/27 00:00
MHDA- 1989/11/27 00:01
CRDT- 1989/11/27 00:00
PHST- 1989/11/27 00:00 [pubmed]
PHST- 1989/11/27 00:01 [medline]
PHST- 1989/11/27 00:00 [entrez]
AID - 0006-8993(89)91707-1 [pii]
AID - 10.1016/0006-8993(89)91707-1 [doi]
PST - ppublish
SO  - Brain Res. 1989 Nov 27;503(1):83-90. doi: 10.1016/0006-8993(89)91707-1.