PMID- 25588317
OWN - NLM
STAT- MEDLINE
DCOM- 20151207
LR  - 20150305
IS  - 1465-3338 (Electronic)
IS  - 0307-9457 (Linking)
VI  - 44
IP  - 2
DP  - 2015
TI  - Comparison of Newcastle disease vaccine administered as powder or liquid in 
      relation to the serum antibody response and adverse vaccinal reactions in 
      broilers.
PG  - 114-23
LID - 10.1080/03079457.2015.1007920 [doi]
AB  - Liquid spray and aerosol mass vaccination of poultry have several drawbacks, such 
      as uncontrolled deposition of vaccine particles in the respiratory tract and 
      vaccine virus inactivation by formation and evaporation of droplets. These may be 
      addressed by using dry powder vaccines with defined particle size distribution 
      targeting the upper (primary vaccination) or the entire respiratory tract 
      (booster vaccination). Therefore, a coarse Newcastle disease (LZ58 strain) powder 
      vaccine was administered to specified pathogen free (SPF) broiler hens to compare 
      the antibody response and adverse vaccinal reactions with those induced by a 
      coarse liquid spray and a fine liquid aerosol. Groups of 40 broilers each housed 
      in isolators were vaccinated at 4 days of age and intratracheally inoculated with 
      Escherichia coli (strain 506) at 11 days of age. Adverse vaccinal reactions were 
      evaluated by measuring body weight gain and mortality between 4 and 11 days of 
      age and between 11 and 18 days of age, and by recording colibacillosis lesions at 
      18 days of age. The antibody serum response was measured at 18 days of age by the 
      haemagglutination inhibition test. Despite the relative low initial vaccine virus 
      loss and narrow particle size distribution of the powder vaccines in comparison 
      with their liquid counter parts, no significant differences (P > 0.05) regarding 
      adverse vaccinal reactions and antibody response were observed between broilers 
      vaccinated with the powder vaccines or with their liquid counterparts.
FAU - Landman, W J M
AU  - Landman WJ
AD  - a GD - Animal Health, Deventer , the Netherlands.
FAU - Huyge, K
AU  - Huyge K
FAU - Remon, J P
AU  - Remon JP
FAU - Vervaet, C
AU  - Vervaet C
FAU - van Eck, J H H
AU  - van Eck JH
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Avian Pathol
JT  - Avian pathology : journal of the W.V.P.A
JID - 8210638
RN  - 0 (Aerosols)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Powders)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Aerosols/*administration & dosage/pharmacology
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Body Weight
MH  - *Chickens
MH  - Escherichia coli
MH  - Escherichia coli Infections/*immunology
MH  - Female
MH  - Newcastle disease virus/*immunology
MH  - Particle Size
MH  - Poultry Diseases/*immunology/microbiology/virology
MH  - Powders/*administration & dosage/pharmacology
MH  - Vaccination/methods/*veterinary
MH  - Viral Vaccines/administration & dosage/*adverse effects
EDAT- 2015/01/16 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/01/16 06:00
PHST- 2015/01/16 06:00 [entrez]
PHST- 2015/01/16 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1080/03079457.2015.1007920 [doi]
PST - ppublish
SO  - Avian Pathol. 2015;44(2):114-23. doi: 10.1080/03079457.2015.1007920.